Results 81 to 90 of about 648,642 (305)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Large-scale plane strain tests on mechanical properties of gravelly soils under unloading and reloading conditions

Yantu gongcheng xuebao
Aiming at the repetitive loading and unloading issue in the plane strain of water conservancy and transportation projects, the large-scale geotechnical triaxial apparatus of Xi'an University of Technology modified with a pressure chamber of plane strain,
WANG Zhi 1, SHAO Shuai 2, SHAO Shengjun 1, 3, YAN Guangyi 4
doaj   +1 more source

Experimentally induced errors in digital image correlation measurement of small strains with large gradients [PDF]

, 2011
Digital Image Correlation or DIC is an already widespread and commonly used technique to perform full field strain measurements. Usually, a so called 'speckle pattern' is put on the specimen and then, pictures are taken first in the undeformed stage ...
Cofaru, Corneliu, De Baere, Ives, Debruyne, Dimitri, Degrieck, Joris, Lammens, Nicolas, Lava, Pascal, Philips, Wilfried, Van Paepegem, Wim   +7 more
core   +1 more source

Influence of strain on anisotropic thermoelectric transport of Bi$_2$Te$_3$ and Sb$_2$Te$_3$

, 2011
On the basis of detailed first-principles calculations and semi-classical Boltzmann transport, the anisotropic thermoelectric transport properties of Bi$_2$Te$_3$ and Sb$_2$Te$_3$ under strain were investigated.
B. Yu. Yavorsky, H. Li, I. Mertig, M. Zhitinskaya, N. F. Hinsche, P. Zahn   +5 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Crack growth measured on flat and curved surfaces at cryogenic temperatures [PDF]

, 1967
Multiple element continuity gage measures plane stress crack growth plus surface crack growth under plane strain conditions.
Orange, T. W., Sullivan, T. L.
core   +1 more source

Influence of elastic strain on the thermodynamics and kinetics of lithium vacancy in bulk LiCoO2

, 2017
The influence of elastic strain on the lithium vacancy formation and migration in bulk LiCoO2 is evaluated by means of first-principles calculations within density functional theory (DFT).
Albe, Karsten, Kaghazchi, Payam, Moradabadi, Ashkan, Rohrer, Jochen   +3 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source