Results 121 to 130 of about 947,996 (305)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Improvement of an integral equation method in plane elasticity through modification of source density representation [PDF]

open access: yes
Integral equation method with continuous functions for calculating boundary stress components in plane ...
Henry, A. S., Rim, K.
core   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Experimental Study on Deformation and Strength of Silt Under Plane Strain Unloading Conditions

open access: yesApplied Sciences
In geotechnical engineering, operations such as foundation pit excavation, slope cutting, and tunnel boring often involve lateral unloading under plane strain conditions.
Jingchao Jia   +4 more
doaj   +1 more source

The equivalence between local inertial frames and electromagnetic gauge in Einstein-Maxwell theories

open access: yes, 2013
We are going to prove that locally the inertial frames and gauge states of the electromagnetic field are equivalent. This proof will be valid for Einstein-Maxwell theories in four-dimensional Lorentzian spacetimes.
Garat, Alcides
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Research on response characteristics of loess slope and disaster mechanism caused by structural plane extension under excavation

open access: yesScientific Reports
Geological disasters occur frequently in the Loess Plateau due to the joint fissures in the strata and human engineering activities. Against this background, the deformation and failure mode of the loess slope with the structural plane under excavation ...
Ranke Fang   +5 more
doaj   +1 more source

The crack problem in bonded nonhomogeneous materials [PDF]

open access: yes
The plane elasticity problem for two bonded half planes containing a crack perpendicular to the interface was considered. The effect of very steep variations in the material properties near the diffusion plane on the singular behavior of the stresses and
Erdogan, Fazil   +2 more
core   +1 more source

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