Results 101 to 110 of about 947,996 (305)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Plane Stress Failure Criterion for Inorganically-Bound Core Materials. [PDF]

Materials (Basel), 2021
Lechner P, Hartmann C, Ettemeyer F, Volk W.   +3 more
europepmc   +1 more source

Beyond the veil: Inner horizon instability and holography

, 2004
We show that scalar perturbations of the eternal, rotating BTZ black hole should lead to an instability of the inner (Cauchy) horizon, preserving strong cosmic censorship.
C. P. Herzog, E. Witten, G. T. Horowitz, G. T. Horowitz, J. M. Maldacena, J. M. Maldacena, L. Fidkowski, N. D. Birrell, R. Penrose, R. Penrose, R. Penrose, S. Chandrasekhar, S. Hemming, V. Balasubramanian   +13 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Shear relaxation behind the shock front in $\langle$110$\rangle$ Molybdenum - From the Atomic Scale to Continuous Dislocation Fields

, 2018
In this work we study shock-induced plasticity in Mo single crystals, impacted along the crystal orientation. In particular, the shear relaxation behind the shock front is quantitatively inspected.
Kositski, Roman, Mordehai, Dan, Sandfeld, Stefan, Steinberger, Dominik   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Stress intensity factors in a cracked infinite elastic wedge loaded by a rigid punch [PDF]

A plane elastic wedge-shaped solid was split through the application of a rigid punch. It was assumed that the coefficient of friction on the the contact area was constant, and the problem had a plane of symmetry with respect to loading and geometry ...
Civelek, M. B., Erdogan, F.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Evolutionary impact of weak structural planes on overloaded anchored slope stability

Scientific Reports
This paper conducts a numerical study exploring the impact of the evolution of a weak structural plane on the overload stability and failure performance of anchored slopes.
Chenxi Miao, Wei Zhang, Mengliang Gao, Anqi Liu, Dongdong Pang   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source