Results 91 to 100 of about 3,522,268 (236)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Numerical investigation of strength and micro-cracking behavior of anisotropic sandstone under true triaxial stress

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
Anisotropy is a common behavior of bedded rock in underground engineering. Evaluating the influence of bedding plane on both mechanical property and failure behavior of anisotropic rock under true triaxial stress is of great importance.
Dang Gao, Jun Peng, Zaobao Liu, Xin Wang, Hanglong Wang   +4 more
doaj   +1 more source

Analysis of residual stress around a Berkovich nano-indentation by micro-Raman spectroscopy

AIP Advances, 2019
Nano-indentation is a destructive measurement that introduces non-uniform residual stress around each nano-indentation. Herein, the residual stress distribution around a Berkovich nano-indentation on (001)- and (111)-plane silicon was studied by micro ...
Lulu Ma, Huadan Xing, Qi Ding, Yuetao Han, Qiu Li, Wei Qiu   +5 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Behaviour of a sandy silt gold tailings under drained simple shear loading in a torsional shear hollow cylinder apparatus

Soils and Foundations
Experimental results are presented in this technical paper to investigate the mechanisms of plane strain consolidation and drained shearing typical of below slope conditions.
Riccardo Fanni, David Reid, Andy Fourie
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Thermoelastic stress analysis of laminated composite materials

, 2009
In this work thermoelastic stress analysis (TSA) is used to obtain quantitative stress/strain data from a variety of multi-directional laminated composites. In order to interpret the thermoelastic signal correctly the source of the thermoelastic response
Sambasivam, Shamala
core   +1 more source

Plane residual stress measurement using ultrasonic considering weak anisotropy of metallic material

AIP Advances, 2018
Ultrasonic velocity variation (UVV) along different directions induced by material weak anisotropy will lead to residual stress measurement error using ultrasonic inevitably.
Yongqing Wang, Yapeng Li, Haibo Liu, Xiang Zhang, Yankun Liu, Kuo Liu   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source