Results 81 to 90 of about 16,976,362 (331)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Developing compatibility biomass model based on UAV LiDAR data of Chinese fir (Cunninghamia lanceolata) in Southern China

Frontiers in Plant Science
Chinese fir (Cunninghamia lanceolata) is a key native tree species in southern China. Accurate estimation of above-ground biomass and its distribution is essential for the sustainable use of Chinese fir forests.
Zheyuan Wu, Dongbo Xie, Ziyang Liu, Qiao Chen, Qiaolin Ye, Jinsheng Ye, Qiulai Wang, Xingyong Liao, Yongjun Wang, Ram P. Sharma, Liyong Fu   +10 more
doaj   +1 more source

Efficiency of adaptive cluster sampling and traditional sampling for coastal mangrove in Hainan of China

Journal of Forest Science, 2012
Based on two species of Coastal Mangrove in Hainan of China, Sonneratia Apetala Buch-Ham and Sonneratia caseoli, we estimated the density of the two species to evaluate the efficiency of adaptive cluster sampling (ACS), simple random sampling (SRS) and ...
Y. Lei, J. Shi, T. Zhao
doaj   +1 more source

Planning and Proof Planning [PDF]

, 1996
. The paper adresses proof planning as a specific AI planning. It describes some peculiarities of proof planning and discusses some possible cross-fertilization of planning and proof planning. 1 Introduction Planning is an established area of Artificial
Bundy, Alan, Melis, E.
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Decreasing Suspended Sediment Concentration and Flux in the Bohai Sea: Based on Remote Sensing and Numerical Simulation

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The Bohai Sea is the region with the highest suspended sediment concentration (SSC) in the world. The transport of suspended sediment from the Bohai Sea to the open sea greatly affects the coastal biogeochemical processes. However, due to the limitations
Xingmin Liu, Lulu Qiao, Guangxue Li, Hongan Sun, Sichen Zhang, Xiaoxia Yu   +5 more
doaj   +1 more source

Extending the use of plateau-escaping macro-actions in planning [PDF]

, 2006
Many fully automated planning systems use a single, domain independent heuristic to guide search and no other problem specific guidance. While these systems exhibit excellent performance, they are often out-performed by systems which are either given ...
Smith, Amanda
core  

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Integrating Optical and SAR Time Series Images for Unsupervised Domain Adaptive Crop Mapping

Remote Sensing
Accurate crop mapping is crucial for ensuring food security. Recently, many studies have developed diverse crop mapping models based on deep learning.
Luwei Feng, Dawei Gui, Shanshan Han, Tianqi Qiu, Yumiao Wang   +4 more
doaj   +1 more source