Results 111 to 120 of about 573,938 (255)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Precipitation Drives Frugivory in a Subtropical Generalist Herbivore, the Gopher Tortoise, and Alters Its Functional Role as a Seed Disperser

Ecology and Evolution
Consumers employ a variety of foraging strategies, and oftentimes the foraging strategy employed is related to resource availability. As consumers acquire resources, they may interact with their resource base in mutualistic or antagonistic ways—falling ...
Adrian Figueroa, Pavel Chernyavskiy, Michael Greenacre, Alyssa Herrera, Lydia Cuni, Jennifer Villate, Mauro Galetti, Hong Liu, Steven Whitfield   +8 more
doaj   +1 more source

Towards a better understanding of the role of nectar-inhabiting yeasts in plant-animal interactions. [PDF]

Fungal Biol Biotechnol, 2020
Klaps J, Lievens B, Álvarez-Pérez S.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Increased resource availability prevents the disruption of key ecological interactions in disturbed habitats

Ecosphere, 2017
Anthropogenic disturbance can modify habitat structure and resource availability, potentially disrupting ecological interactions. This issue may be critical for pollination and seed dispersal, which determine natural regeneration. The mistletoe Tristerix
Francisco E. Fontúrbel, Daniela A. Salazar, Rodrigo Medel   +2 more
doaj   +1 more source

Biological Plausibility of the Pace of Creation Written in the Genesis [PDF]

, 2012
The purpose of this paper is to discuss the biological plausibility of the pace of creation written in the genesis. A fascinating hypothesis is made on the central role of serotonin as a guide, as the director of the phenomena that ...
Cocchi, Massimo
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Plant-animal interactions between carnivorous plants, sheet-web spiders, and ground-running spiders as guild predators in a wet meadow community. [PDF]

Ecol Evol, 2020
Krupa JJ, Hopper KR, Gruber SB, Schmidt JM, Harwood JD.   +4 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source