Results 91 to 100 of about 573,938 (255)

Effects of organic and ‘low input’ production methods on food quality and safety [PDF]

, 2007
The intensification of agricultural production in the last century has resulted in a significant loss of biodiversity, environmental problems and associated societal costs.
Butler, G., Cooper, J.M., Leifert, C., Lueck, L., Nielson, J.H., Rembiałkowska, E.   +5 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Multi‐Species Canopy Latrines in Costa Rican Cloud Forests: A Mammal Interactions Hub in a Single Tree Species

Ecology and Evolution
We report the discovery of arboreal multi‐species mammal latrines in montane cloud forests of Costa Rica. We surveyed 169 trees from 29 species. Canopy multi‐species latrines were only found in 11 individuals of a single tree species, Ficus tuerckheimii.
Jeremy Quirós‐Navarro, Tim Chamberlain, Deiver Espinoza   +2 more
doaj   +1 more source

Comparison of methods for determining the fatty acid composition of photosynthetic tissues [PDF]

The fatty acid (FA) composition of photosynthetic tissue differs from that in other plant or animal tissues. In leaves, the lipid fraction constitutes less than 10% of the dry weight and is mostly located in the chloroplasts. An extraction solvent should
Arvidsson, K., Elgersma, A., Fievez, V., Gustavsson, A.M., Lourenço, M., Witkowska, I.M.   +5 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Persistence of the African baobab (Adansonia digitata L.) in a system experiencing chronic utilization by elephants

Conservation Science and Practice
Chronic utilization of woody vegetation by African savanna elephants may transform woodland vegetation to open savanna and threaten the extirpation of targeted species.
Jarryd Foster, Timothy O'Connor, Vernon Visser, Timm Hoffman   +3 more
doaj   +1 more source

Cropping System Conversion led to Organic Carbon Change in China’s Mollisols Regions

Scientific Reports, 2017
Land use change driven by diet, globalization, and technology advancement have greatly influenced agricultural production and environment in the mollisols region of China, with a marked impact on the depletion of soil organic matter, a signature property
Yuxin Tong, Jianguo Liu, Xiaolin Li, Jing Sun, Anna Herzberger, Dan Wei, Weifeng Zhang, Zhengxia Dou, Fusuo Zhang   +8 more
doaj   +1 more source

Receptors and Signaling Pathways for Recognition of Bacteria in Livestock and Crops: Prospects for Beneficial Microbes in Healthy Growth Strategies

Frontiers in Immunology, 2018
Modern animal and crop production practices are associated with the regular use of antimicrobials, potentially increasing selection pressure on bacteria to become resistant. Alternative approaches are needed in order to satisfy the demands of the growing
Julio Villena, Julio Villena, Haruki Kitazawa, Haruki Kitazawa, Saskia C. M. Van Wees, Corné M. J. Pieterse, Hideki Takahashi, Hideki Takahashi   +7 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source