Results 91 to 100 of about 6,685,461 (209)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Functional and applied aspects of the DOWNY MILDEW RESISTANT 1 and 6 genes in Arabidopsis [PDF]
, 2012 Plants are constantly exposed to micro-organisms including pathogens. They are resistant to the vast majority of potential pathogens due to a multilayered defence system. Plant disease susceptibility, on the other hand, is determined by virulence factors
Zeilmaker, T. +2 more
core +1 more source
Modulation of host immunity by beneficial microbes [PDF]
, 2012 In nature, plants abundantly form beneficial associations with soilborne microbes that are important for plant survival and, as such, affect plant biodiversity and ecosystem functioning.
Pieterse, C.M.J. +5 more
core +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Conservation Science and PracticeChronic utilization of woody vegetation by African savanna elephants may transform woodland vegetation to open savanna and threaten the extirpation of targeted species.
Jarryd Foster +3 more
doaj +1 more source
Soil nutrient availability affects tundra plant community composition and plant–vole interactions
Arctic, Antarctic, and Alpine ResearchClimate change in the Arctic is predicted to drastically alter carbon and nutrient pools, plant communities, and plant–animal interactions. We examined how four levels of long-term (16 years) nutrient addition in moist acidic tundra affected plant ...
Nicole Williamson +2 more
doaj +1 more source
The soil-borne supremacy [PDF]
, 2016 The rhizosphere microbiome plays an important role in plant growth, nutrition and health. Recent research unearthed that plant genotype-dependent navigation of microbial community composition in the rhizosphere is associated with fitness consequences for
de Jonge, Ronnie +4 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
An on-farm investigation of beef suckler herds using an animal welfare index (AWI) [PDF]
, 2010 peer-reviewedBackground: Beef suckler farms (194 farms throughout 13 counties) were assessed once with housed cattle and once with cattle at grass using an animal welfare index (AWI).
Veissier Isabelle +16 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source