Results 81 to 90 of about 6,685,461 (209)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Emerging roles of tetraspanins in plant inter-cellular and inter-kingdom communication
Plant Signaling & Behavior, 2019 Inter-cellular and inter-kingdom signaling systems of various levels of complexity regulate pathogenic and mutualistic interactions between bacteria, parasites, and fungi and animal and plant hosts. Inter-kingdom interactions between mutualistic bacteria
Saul Jimenez-Jimenez +5 more
doaj +1 more source
Induced disease resistance [PDF]
, 2015 During the co-evolutionary arms race between plants and pathogens, plants evolved a sophisticated defense system to ward off their enemies. In this plant immune system, plant receptor proteins recognize non-self molecules of microbial origin, which leads
van Wees, Saskia +4 more
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Microbial control of root-pathogenic fungi and oomycetes [PDF]
, 2015 The rhizosphere is a complex and dynamic environment in which microbes introduced to control root pathogens must establish and maintain populations of sufficient size and activity to antagonize pathogens directly or by manipulating the host plant’s own ...
Bakker, P.A.H.M. +5 more
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Ecosphere, 2017 Escaping seed predation is a classic “economy of scale” hypotheses (predator satiation hypothesis, Psh) to explain the selection for the synchronous production of massive and nil seed crops (masting) in plants.
Josep Maria Espelta +5 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Molecular and functional analysis of novel regulators of defense hormone signaling [PDF]
, 2019 Hormones are central regulators of plant immunity. They can trigger large-scale reprogramming of the plant’s transcriptome, and influence each other in an antagonistic or synergistic manner.
Sub Plant-Microbe Interactions +2 more
core
Mass Spectral Imaging to Map Plant–Microbe Interactions
, 2023 Plant–microbe interactions are of rising interest in plant sustainability, biomass production, plant biology, and systems biology. These interactions have been a challenge to detect until recent advancements in mass spectrometry imaging. Plants and
Xiao-Ying Yu +2 more
core +1 more source