Results 111 to 120 of about 570,705 (308)

STABILITY ANALYSIS OF ECOLOGICAL MODELS OF PLANT-ANIMAL INTERACTIONS IN RIPARIAN ZONES [PDF]

Proceedings on Engineering Sciences
The research summarizes the essential findings and open topics from previous stability analyses of models involving Riparian zones. These models are central to tropic interactions, ecological complexity, and species coexistence.
Ravi Kiran Duvvuri , Rami Reddy Bhavanam , G. V. Ramana , Venkat Rao Kanuri   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A Comparative Review on Microbiota Manipulation: Lessons From Fish, Plants, Livestock, and Human Research

Frontiers in Nutrition, 2018
During recent years the impact of microbial communities on the health of their host (being plants, fish, and terrestrial animals including humans) has received increasing attention.
Sylvia Brugman, Wakako Ikeda-Ohtsubo, Saskia Braber, Gert Folkerts, Corné M. J. Pieterse, Peter A. H. M. Bakker   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Importancia de la heterogeneidad ambiental en la ecología de plantas carnívoras mediterráneas: implicaciones para la conservación Environmental heterogeneity and the ecology of carnivorous plants: implications for conservation

Revista Chilena de Historia Natural, 2002
En la cuenca mediterránea, la mayoría de las plantas carnívoras pertenecientes al género Pinguicula habitan las paredes húmedas de montañas calizas. Estos escenarios rocosos condicionan la ecología de las poblaciones situadas en distintos exposiciones ...
Regino Zamora
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Multi‐Species Canopy Latrines in Costa Rican Cloud Forests: A Mammal Interactions Hub in a Single Tree Species

Ecology and Evolution
We report the discovery of arboreal multi‐species mammal latrines in montane cloud forests of Costa Rica. We surveyed 169 trees from 29 species. Canopy multi‐species latrines were only found in 11 individuals of a single tree species, Ficus tuerckheimii.
Jeremy Quirós‐Navarro, Tim Chamberlain, Deiver Espinoza   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source