Results 91 to 100 of about 18,169,085 (292)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Biofilm Inhibition Against Staphylococcus aureus and Alizarin Red Dye-Removing Capability of Plant-Based Green Synthesis of Lanthanum Oxide (La₂O₃NPs) Nanoparticles

Reactions
The unique properties of lanthanum oxide nanoparticles (La2O3NPs) make them highly suitable for various environmental applications. This study explores the plant-based synthesis of La2O3NPs using Drypetes sepiaria as a reducing agent.
Krishnamoorthy Uma Sivakami, Sundararajan Vaideeswaran, Ambrose Rosevenis, Rajender Boddula, Kanagarajan Shenbagam, Muniraj Balaganesh, Usan Pathinathan Saleth Prabhakar, Paramasivam Shanmugam, Fatemah M. Barakat, Supakorn Boonyuen, Ramyakrishna Pothu   +10 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Difference in Motives and Basic Health Behavior of 8799 Children and Adolescents Aged 10–19 Years Following a Vegan, Vegetarian, or Omnivorous Diet

Current Developments in Nutrition
Background: Young generations appear to be pushing for more sustainable food production as part of the trend toward healthier dietary habits. Long-term sustainable healthy behavior from secondary school ages may contribute to the life course prevention ...
Katharina C Wirnitzer, Derrick R Tanous, Clemens Drenowatz, Gerold Wirnitzer, Manuel Schätzer, Gerhard Ruedl, Werner Kirschner   +6 more
doaj   +1 more source

Nutrition Interventions in Rheumatoid Arthritis: The Potential Use of Plant-Based Diets. A Review

Frontiers in Nutrition, 2019
Rheumatoid arthritis (RA), a chronic inflammatory autoimmune disease, affects roughly 1% of the world's population. RA pathogenesis remains unclear, but genetic factors account for 50–60% of the risk while the remainder might be linked to modifiable ...
Jihad Alwarith, Hana Kahleova, Emilie Rembert, Willy Yonas, Sara Dort, Manuel Calcagno, Nora Burgess, Lee Crosby, Neal D. Barnard, Neal D. Barnard   +9 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Commission on Evidence-Based Policymaking

, 2017
Website for the Commission on Evidence-Based Policymaking (CEP), which was established to create a strategy for increasing access to data about government programs while protecting confidentiality. It includes hearings, meeting minutes, and news as well
United States. Commission on Evidence-Based Policymaking.
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source