Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
SLocX: Predicting subcellular localization of Arabidopsis proteins leveraging gene expression data
Frontiers in Plant Science, 2011 Despite the growing volume of experimentally validated knowledge about the subcellular localization of plant proteins, a well performing in-silico prediction tool is still a necessity.
Malgorzata eRyngajllo +6 more
doaj +1 more source
Spectral Effects of Artificial Light on Plant Physiology and Secondary Metabolism: A Review
, 2015 With the expeditious development of optoelectronics, the light-emitting diode (LED) technology as supplementary light has shown great advancement in protected cultivation.
Theoharis Ouzounis +2 more
semanticscholar +1 more source
Journal of Plant Growth Regulation, 2015 Uncertainties about the response of plant photosynthesis and growth to elevated temperature make it difficult to predict how plant production will vary under future climatic warming in alpine regions.
Gang Fu +5 more
semanticscholar +1 more source
Arsenate Impact on the metabolite profile, production, and arsenic loading of xylem sap in cucumbers (Cucumis sativus L.) [PDF]
, 2012 Peer ...
Feldmann, Jörg +3 more
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The effects of cycocel (CCC) on tomato under water stress [PDF]
, 1983 Thesis (M.Ag.Sci.) -- University of Adelaide, Dept.
Amoabin, Solomon
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source