Results 111 to 120 of about 2,977,871 (300)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Comparative analysis of the composition and carbohydrate content in the fruits of M. baccata (L.) Borkh. and its hybrid varieties with M. domestica Borkh.

Siberian Journal of Life Sciences and Agriculture
Background. Research studies of the composition and content of carbohydrates in fruits of the hybrid varieties Malus baccata (L.) Borkh. and Malus domestica Borkh., which are widespread in cold climates, are important both from a fundamental point of ...
Elena G. Rudikovskaya, Zlata O. Stavitskaya, Lyubov V. Dudareva, Natalia V. Semenova, Natalia B. Katysheva, Alexander V. Rudikovskii   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Leaf development regulates state transition capacity in trees

Nature Communications
State transitions (ST) balance excitation energy between photosystem I and II. This process has been extensively studied in Arabidopsis but the regulation and physiological significance of ST in other angiosperms remain largely unknown.
Chen Hu, Sanchali Nanda, Maria Dolores Pissolato, Maximiliano Cainzos, Tatyana Shutova, Stefan Jansson   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Scientific Development of the Physiology of Plants in the American Tropics

Revista de Biología Tropical, 2002
This paper is a research and journalistic work that summarizes and synthesizes the scientific development of the physiology of plants in the American tropics, also known as the Neotropics.
Marco V. Gutiérrez
doaj  

The “plant neurobiology” revolution

Plant Signaling & Behavior
The 21st-century “plant neurobiology” movement is an amalgam of scholars interested in how “neural processes”, broadly defined, lead to changes in plant behavior.
Peter V. Minorsky
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Hit-Gel: Streamlining in-gel protein digestion for high-throughput proteomics experiments

Scientific Reports, 2018
In-gel digestion has been used as a standard method for the preparation of protein samples for mass spectrometry analysis for over 25 years. Traditional in gel-digestion procedures require extensive sample handling, are prone to contamination and not ...
Corné Swart, Silvia Martínez-Jaime, Michal Gorka, Kerstin Zander, Alexander Graf   +4 more
doaj   +1 more source