Results 141 to 150 of about 527,889 (294)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Natural medicinal plant products as an immune-boosters: A possible role to lessen the impact of Covid-19. [PDF]

Case Stud Chem Environ Eng, 2021
Islam SS, Midya S, Sinha S, Saadi SMAI.
europepmc   +1 more source

Perspective: Identifying Ultra-Processed Plant-Based Milk Alternatives in the USDA Branded Food Products Database

, 2021
Adam Drewnowski
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Chromosome-level genome assembly of the predatory flower bug Orius strigicollis

Scientific Data
Predatory insects serve as important biological control agents in ecosystems by efficiently reducing pest populations. Orius strigicollis is a highly effective beneficial predator in cultivated fields in China.
Yaru Wang, Limin Chen, Farman Ullah, Liqiu Wang, Shuxing Zhou, Jun Huang, Zhijun Zhang, Jinming Zhang, Wanying Dong, Min Liu, Shengyuan Zhao, Xiaowei Li, Yaobin Lu   +12 more
doaj   +1 more source

Influence of positioning the rows direction in sowing second beans the ratio of the sun in the zenith on the plants photosynthetic productivity, yield and product quality

, 2022
О. В. Овчарук, S.M. Kalenska, O.V. Tkach, V.I. Ovcharuk   +3 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Biotechnological Upgrade of High Fiber-Low Protein Industrial Plant By-products in Broiler Diets: Haematology and Serum Evaluation

, 2018
A.O. Fasuyi, D Akinboyowa
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

WASTE RECYCLING POLYOLEFINS PROCESS IMPLEMENTATION IN A GRANULATED PRODUCT AT JSC «ANGARSK POLYMER PLANT»

, 2020
Vsevolod Bashkircev, Tat'yana Raskulova
openalex   +2 more sources