Results 41 to 50 of about 128,391 (216)

The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity

Nature Communications, 2018
Steatosis is characterized by initial accumulation of lipids, followed by inflammation and ultimately fibrosis. Here the authors show that the histone demethylase Plant Homeodomain Finger 2 protects liver form steatosis progression by acting as a co ...
Julien Bricambert, Marie-Clotilde Alves-Guerra, Pauline Esteves, Carina Prip-Buus, Justine Bertrand-Michel, Hervé Guillou, Christopher J. Chang, Mark N. Vander Wal, François Canonne-Hergaux, Philippe Mathurin, Violeta Raverdy, François Pattou, Jean Girard, Catherine Postic, Renaud Dentin   +14 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The Q-System as a Synthetic Transcriptional Regulator in Plants

Frontiers in Plant Science, 2020
A primary focus of the rapidly growing field of plant synthetic biology is to develop technologies to precisely regulate gene expression and engineer complex genetic circuits into plant chassis.
Ramona Persad, Ramona Persad, Ramona Persad, D. Nikki Reuter, D. Nikki Reuter, Lezlee T. Dice, Lezlee T. Dice, Mary-Anne Nguyen, Mary-Anne Nguyen, Stephen B. Rigoulot, Stephen B. Rigoulot, Jessica S. Layton, Jessica S. Layton, Manuel J. Schmid, Manuel J. Schmid, Magen R. Poindexter, Magen R. Poindexter, Alessandro Occhialini, Alessandro Occhialini, C. Neal Stewart, C. Neal Stewart, Scott C. Lenaghan, Scott C. Lenaghan   +22 more
doaj   +1 more source

Effects of stress-induced ABA on root architecture development: Positive and negative actions

Crop Journal, 2023
Root architecture development, an agronomic trait that influences crop yield, is regulated by multiple plant hormones. Abscisic acid (ABA) is a stress hormone that responds to multiple stresses, including salt, drought, and cold stress, and modulates ...
Zhenning Teng, Jiahan Lyu, Yinke Chen, Jianhua Zhang, Nenghui Ye   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Biochar from Chlorella sp. algae as a plant growth activator

Scientific Reports
Modern agriculture has been looking for effective and ecological sources supporting plant growth, but there are no natural stimulants on the market.
Karolina Dziosa, Monika Makowska
doaj   +1 more source

The Development of Mitochondrial Gene Editing Tools and Their Possible Roles in Crop Improvement for Future Agriculture

Advanced Genetics, 2022
We are living in the era of genome editing. Nowadays, targeted editing of the plant nuclear DNA is prevalent in basic biological research and crop improvement since its first establishment a decade ago.
Jinghua Yang, Xiaodong Yang, Tongbing Su, Zhongyuan Hu, Mingfang Zhang   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source