Results 111 to 120 of about 229,059 (307)
Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti +9 morewiley +1 more sourceTau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido +3 morewiley +1 more sourceCalpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan +4 morewiley +1 more sourceA methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück +13 morewiley +1 more sourceTRY plant trait database - enhanced coverage and open access [PDF]
, 2020 Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits ...Aakala, T, Abedi, M, Acosta, ATR, Adamidis, GC, Adamson, K, Aiba, M, Albert, CH, Alcantara, JM, Alcazar, CC, Aleixo, I, Ali, H, Amiaud, B, Ammer, C, Amoroso, MM, Anand, M, Anderson, C, Anh, TDL, Anten, N, Antos, J, Apgaua, DMG, Ashman, TL, Asmara, DH, Asner, GP, Aspinwall, M, Atkin, O, Aubin, I, Baastrup-Spohr, L, Bahalkeh, K, Bahn, M, Baker, T, Baker, WJ, Bakker, JP, Baldocchi, D, Baltzer, J, Banerjee, A, Baranger, A, Barlow, J, Barneche, DR, Baruch, Z, Bastianelli, D, Battles, J, Bauerle, W, Bauters, M, Bazzato, E, Beckmann, M, Beeckman, H, Beierkuhnlein, C, Bekker, R, Belfry, G, Belluau, M, Beloiu, M, Benavides, R, Benomar, L, Berdugo-Lattke, ML, Berenguer, E, Bergamin, R, Bergmann, J, Berner, L, Bernhardt-Romermann, M, Bigler, C, Bjorkman, AD, Blackman, C, Blanco, C, Blonder, B, Blumenthal, D, Bocanegra-Gonzalez, KT, Boeckx, P, Bohlman, S, Bohning-Gaese, K, Boisvert-Marsh, L, Bond, W, Bond-Lamberty, B, Bonisch, G, Boom, A, Boonman, CCF, Bordin, K, Boughton, EH, Boukili, V, Bowman, DMJS, Bravo, S, Brendel, MR, Broadley, MR, Brown, KA, Bruelheide, H, Brumnich, F, Bruun, HH, Bruy, D, Buchanan, SW, Bucher, SF, Buchmann, N, Buitenwerf, R, Bunker, DE, Burger, J, Burrascano, S, Burslem, DFRP, Butterfield, BJ, Byun, C, Caccianiga, M, Cadotte, M, Cailleret, M, Camac, J, Camarero, JJ, Campany, C, Campetella, G, Campos, JA, Cano-Arboleda, L, Canullo, R, Carbognani, M, Carlucci, MB, Carvalho, F, Casanoves, F, Castagneyrol, B, Catford, JA, Cavender-Bares, J, Cerabolini, BEL, Cervellini, M, Chacon-Madrigal, E, Chapin, FS, Chapin, K, Chelli, S, Chen, AP, Chen, SC, Cherubini, P, Chianucci, F, Choat, B, Chung, KS, Chytry, M, Ciccarelli, D, Coll, L, Collins, CG, Conti, L, Coomes, D, Cornelissen, JHC, Cornwell, WK, Corona, P, Coyea, M, Craine, J, Craven, D, Cromsigt, JPGM, Csecserits, A, Cufar, K, Cuntz, M, da Silva, AC, Dahlin, KM, Dainese, M, Dalke, I, Dalle Fratte, M, Danihelka, J, Dannoura, M, Dawson, S, de Beer, AJ, de Dios, VR, De Frutos, A, de Gasper, AL, De Long, JR, Dechant, B, Delagrange, S, Delpierre, N, Derroire, G, Dias, AS, Diaz, S, Diaz-Toribio, MH, Dimitrakopoulos, PG, Dobrowolski, M, Doktor, D, Domingues, TF, Dong, N, Dransfield, J, Dressler, S, Drevojan, P, Duarte, L, Ducouret, E, Dullinger, S, Durka, W, Duursma, R, Dymova, O, E-Vojtko, A, Eckstein, RL, Ejtehadi, H, Elser, J, Emilio, T, Engemann, K, Erfanian, MB, Erfmeier, A, Esquivel-Muelbert, A, Esser, G, Estiarte, M, Fagan, WF, Fagundez, J, Falster, DS, Fan, Y, Fang, JY, Farris, E, Fazlioglu, F, Feng, YH, Fernandez-Mendez, F, Ferrara, C, Ferreira, J, Fidelis, A, Finegan, B, Firn, J, Flowers, TJ, Flynn, DFB, Fontana, V, Forey, E, Forgiarini, C, Francois, L, Frangipani, M, Frank, D, Frenette-Dussault, C, Freschet, GT, Fry, EL, Fyllas, NM, Gachet, S, Gallagher, R, Ganade, G, Ganga, F, Garcia-Palacios, P, Gargaglione, V, Garnier, E, Garrido, JL, Garvizu, GS, Gea-Izquierdo, G, Gibson, D, Gillison, AN, Giroldo, A, Glasenhardt, MC, Gleason, S, Gliesch, M, Goldberg, E, Goldel, B, Gonzalez-Akre, E, Gonzalez-Andujar, JL, Gonzalez-Melo, A, Gonzalez-Robles, A, Graae, BJ, Granda, E, Graves, S, Green, WA, Gregor, T, Gross, N, Guerin, GR, Gunther, A, Gutierrez, AG, Haddock, L, Haines, A, Hall, J, Hambuckers, A, Han, WX, Harrison, SP, Hattingh, W, Hawes, JE, He, PC, He, TH, Heberling, JM, Helm, A, Hempel, S, Hentschel, J, Herault, B, Heres, AM, Herz, K, Heuertz, M, Hickler, T, Hietz, P, Higuchi, P, Hipp, AL, Hirons, A, Hock, M, Hogan, JA, Holl, K, Honnay, O, Hornstein, D, Hou, EQ, Hough-Snee, N, Hovstad, KA, Ichie, T, Igic, B, Illa, E, Isaac, M, Ishihara, M, Ivanov, L, Ivanova, L, Iversen, CM, Izquierdo, J, Jackson, B, Jackson, RB, Jactel, H, Jagodzinski, AM, Jandt, U, Jansen, S, Jenkins, T, Jentsch, A, Jespersen, JRP, Jiang, GF, Johansen, JL, Johnson, D, Jokela, EJ, Joly, CA, Jordan, GJ, Joseph, GS, Junaedi, D, Junker, RR, Justes, E, Kabzems, R, Kane, J, Kaplan, Z, Kattenborn, T, Kattge, J, Kavelenova, L, Kearsley, E, Kempel, A, Kenzo, T, Kerkhoff, A, Khalil, MI, Kinlock, NL, Kissling, WD, Kitajima, K, Kitzberger, T, Kjoller, R, Klein, T, Kleyer, M, Klimesova, J, Klipel, J, Kloeppel, B, Klotz, S, Knops, JMH, Kohyama, T, Koike, F, Kollmann, J, Komac, B, Komatsu, K, Konig, C, Kraft, NJB, Kramer, K, Kreft, H, Kuhn, I, Kumarathunge, D, Kuppler, J, Kurokawa, H, Kurosawa, Y, Kuyah, S, Laclau, JP, Lafleur, B, Lallai, E, Lamb, E, Lamprecht, A, Larkin, DJ, Laughlin, D, Lavorel, S, Le Bagousse-Pinguet, Y, le Maire, G, le Roux, E, le Roux, PC, Leadley, P, Lee, T, Lens, F, Lewis, SL, Lhotsky, B, Li, XE, Li, YZ, Lichstein, JW, Liebergesell, M, Lim, JY, Lin, YS, Linares, JC, Liu, CJ, Liu, DJ, Liu, U, Livingstone, S, Llusia, J, Lohbeck, M, Lopez-Garcia, A, Lopez-Gonzalez, G, Lososova, Z, Louault, F, Lukacs, BA, Lukes, P, Luo, YJ, Lussu, M, Ma, SY, Mack, M, Maire, V, Makela, A, Makinen, H, Malhado, ACM, Mallik, A, Manning, P, Manzoni, S, Marchetti, Z, Marchino, L, Marcilio-Silva, V, Marcon, E, Marignani, M, Markesteijn, L, Marques, M, Martin, A, Martinez-Garza, C, Martinez-Vilalta, J, Maskova, T, Mason, K, Mason, N, Massad, TJ, Masse, J, Mayrose, I, Mazzochini, GG, McCarthy, J, McCormack, ML, McCulloh, K, McFadden, IR, McGill, BJ, McPartland, MY, Medeiros, JS, Medlyn, B, Meerts, P, Mehrabi, Z, Meir, P, Melo, FPL, Mencuccini, M, Meredieu, C, Messier, J, Meszaros, I, Metsaranta, J, Michaletz, ST, Michelaki, C, Migalina, S, Milla, R, Miller, JED, Minden, V, Ming, R, Mokany, K, Moles, AT, Molnar, VA, Molofsky, J, Molz, M, Montgomery, RA, Monty, A, Moravcova, L, Moreno-Martinez, A, Moretti, M, Mori, AS, Mori, S, Morris, D, Morrison, J, Mucina, L, Mueller, S, Muir, CD, Muller, SC, Munoz, F, Myers-Smith, IH, Myster, RW, Nagano, M, Naidu, S, Narayanan, A, Natesan, B, Negoita, L, Nelson, AS, Neuschulz, EL, Ni, J, Niedrist, G, Nieto, J, Niinemets, U, Nolan, R, Nottebrock, H, Nouvellon, Y, Novakovskiy, A, Nystuen, KO, O'Grady, A, O'Hara, K, O'Reilly-Nugent, A, Oakley, S, Oberhuber, W, Ohtsuka, T, Oliveira, R, Ollerer, K, Olson, ME, Onipchenko, V, Onoda, Y, Onstein, RE, Ordonez, JC, Osada, N, Ostonen, I, Ottaviani, G, Otto, S, Overbeck, GE, Ozinga, WA, Pahl, AT, Paine, CET, Pakeman, RJ, Papageorgiou, AC, Parfionova, E, Partel, M, Patacca, M, Paula, S, Paule, J, Pauli, H, Pausas, JG, Peco, B, Penuelas, J, Perea, A, Pereira, CMR, Peri, PL, Petisco-Souza, AC, Petraglia, A, Petritan, AM, Phillips, OL, Pierce, S, Pillar, VD, Pinho, BX, Pisek, J, Pomogaybin, A, Poorter, H, Portsmuth, A, Poschlod, P, Potvin, C, Pounds, D, Powell, AS, Power, SA, Prentice, IC, Prinzing, A, Puglielli, G, Pysek, P, Raevel, V, Rammig, A, Ransijn, J, Ray, CA, Reich, PB, Reichstein, M, Reid, DEB, Rejou-Mechain, M, Ribeiro, S, Richardson, S, Riibak, K, Rillig, MC, Riviera, F, Robert, EMR, Roberts, S, Robroek, B, Roddy, A, Rodrigues, AV, Rogers, A, Rollinson, E, Rolo, V, Romermann, C, Ronzhina, D, Roscher, C, Rosell, JA, Rosenfield, MF, Rossi, C, Roy, DB, Royer-Tardif, S, Ruger, N, Ruiz-Peinado, R, Rumpf, SB, Rusch, GM, Ryo, M, Sack, L, Saldana, A, Salgado-Negret, B, Salguero-Gomez, R, Santa-Regina, I, Santacruz-Garcia, AC, Santos, J, Sardans, J, Scalon, MC, Schamp, B, Scherer-Lorenzen, M, Schleuning, M, Schmid, B, Schmidt, M, Schmitt, S, Schneider, JV, Schowanek, SD, Schrader, J, Schrodt, F, Schuldt, B, Schurr, F, Semchenko, M, Seymour, C, Sfair, JC, Sharpe, JM, Sheppard, CS, Sheremetiev, S, Shiodera, S, Shipley, B, Shovon, TA, Siebenkas, A, Sierra, C, Silva, M, Silva, V, Sitzia, T, Sjoman, H, Slot, M, Smith, NG, Sodhi, D, Soltis, D, Soltis, P, Somers, B, Sonnier, G, Sorensen, MV, Sosinski, EE, Soudzilovskaia, NA, Souza, AF, Spasojevic, M, Sperandii, MG, Stan, AB, Stegen, J, Steinbauer, K, Stephan, JG, Sterck, F, Stojanovic, DB, Strydom, T, Suarez, ML, Svenning, JC, Svitkova, I, Svitok, M, Svoboda, M, Swaine, E, Swenson, N, Tabarelli, M, Takagi, K, Tappeiner, U, Tarifa, R, Tarin, T, Tautenhahn, S, Tauugourdeau, S, Tavsanoglu, C, te Beest, M, Tedersoo, L, Thiffault, N, Thom, D, Thomas, E, Thompson, K, Thornton, PE, Thuiller, W, Tichy, L, Tissue, D, Tjoelker, MG, Tng, DYP, Tobias, J, Torok, P, Torres-Ruiz, JM, Tothmeresz, B, Treurnicht, M, Trivellone, V, Trolliet, F, Trotsiuk, V, Tsakalos, JL, Tsiripidis, I, Tysklind, N, Umehara, T, Usoltsev, V. A., Vadeboncoeur, M, Vaezi, J, Valderrama, MY, Valladares, F, Vamosi, J, van Bodegom, PM, van Breugel, M, Van Cleemput, E, van de Weg, M, van der Merwe, S, van der Plas, F, van der Sande, MT, van Kleunen, M, Van Meerbeek, K, Vanderwel, M, Vanselow, KA, Varhammar, A, Varone, L, Vassilev, K, Vellend, M, Veneklaas, EJ, Verbeeck, H, Verheyen, K, Vibrans, A, Vieira, I, Villacis, J, Violle, C, Vivek, P, Wagner, K, Waldram, M, Waldron, A, Walker, AP, Waller, M, Walther, G, Wang, F, Wang, H, Wang, WQ, Watkins, H, Watkins, J, Weber, U, Weedon, JT, Wei, LP, Weigelt, P, Weiher, E, Wells, AW, Wellstein, C, Wenk, E, Werner, GDA, Westoby, M, Westwood, A, White, PJ, Whitten, M, Williams, M, Winkler, DE, Winter, K, Wirth, C, Womack, C, Wright, IJ, Wright, J, Wright, SJ, Ximenes, F, Yamada, T, Yamaji, K, Yanai, R, Yankov, N, Yguel, B, Zanini, KJ, Zanne, AE, Zeleny, D, Zhao, YP, Zheng, J, Zheng, JM, Zieminska, K, Zirbel, CR, Zizka, G, Zo-Bi, IC, Zotz, G +727 morecore Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.Ilaria Chiaradia, Madeline A. Lancasterwiley +1 more sourceHyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky +11 morewiley +1 more source
