Results 161 to 170 of about 2,909,796 (290)

Grafting of Black Pepper onto Native <i>Piper</i> Species. [PDF]

Plants (Basel)
Cerri Neto B, Oliveira VS, Marchiori JJP, Crasque J, Ferreira TR, Fernandes SA, Dias CDS, Arantes LO, Ramos EP, Falqueto AR, Schmildt ER, Dousseau-Arantes S.   +11 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Hashimoto Lecture: Upper Extremities and Dorsal Anatomy

Dr. Edward I.

core  

An introduction to the fundamentals of root systems research in cultivated plants. [PDF]

Ann Bot
Jones DH, Tawale AB, Schneider HM.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The metabolic and anatomical complexity of root microhabitats modulate their interaction with the microbiota. [PDF]

Nat Commun
Frene JP, Custódio V, Rouco H, Martinez-Jarquin S, Gao YQ, di Bari V, Bakhoum N, Northen TR, Bowen BP, Louie KB, Velchova K, Ware A, Bishopp A, Mata A, Castrillo G.   +14 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

The co-evolution of hominins and Stone Age culture. [PDF]

Proc Biol Sci
Key A.
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Enhanced Levels of Combined Waterlogging and Heat Stress Exacerbate Anatomical Damage, Photosynthetic Impairment, and Oxidative Stress in Tomato. [PDF]

Antioxidants (Basel)
Qin W, Li Y, Sun Y, Rivero RM, Song X, Mittler R, Jiang F, Wu Z, Xiao D, Yang X, Zhou R.   +10 more
europepmc   +1 more source