Results 191 to 200 of about 229,797 (353)

Physiological Plant AnatomyPhysiologische Pflanzenanatomie. G. Haberlandt [PDF]

, 1897
Emily L. Gregory
openalex   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Correction: Floral anatomy and ultrastructure of Lepanthes calodictyon, L. saltatrix and L. tentaculata (Orchidaceae). [PDF]

BMC Plant Biol
Rykaczewski M, Kapusta M, Narajczyk M, Łuszczek D, Brzezicka E, Szlachetko DL, Małgorzata K.   +6 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Node of origin matters: comparative analysis of soil water limitation effects on nodal root anatomy in maize (Zea mays). [PDF]

Ann Bot
Koehler T, Kim Y, Tung SY, Heymans A, Tyborski N, Steiner F, Wild AJ, Pausch J, Ahmed MA, Schneider HM.   +9 more
europepmc   +1 more source

Phytotoxicity and leaf anatomy of young coffee plants subjected to herbicides exclusively and in associations

, 2020
Rafael Jorge de almeida, Adenilson Henrique Gonçalves, Pedro Menicucci Netto, Arthur Henrique Cruvinel Carneiro, Dalyse Toledo Castanheira, Rubens José Guimarães, Gladyston Rodrigues Carvalho   +6 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Earliest evolution of stipules among vascular plants documented in the late Paleozoic stem group of Marattiales. [PDF]

BMC Biol
Zhou W, Sun W, Wang T, Li D, Pšenička J, Hill C, Boyce CK, Wang J.   +7 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Effects of Toxic Concentrations of Cadmium, Lead, or Zinc on Leaf Morphology, Anatomy and Calcium Oxalate Content in Metallicolous and Non-Metallicolous Ecotypes of <i>Dianthus carthusianorum</i> L. [PDF]

Plants (Basel)
Borkowska-Drela I, Domaciuk M, Szczuka E, Vangronsveld J, Wójcik M.   +4 more
europepmc   +1 more source