Results 61 to 70 of about 4,731,570 (257)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Evolution of Plant Architecture in Oryza Driven by the PROG1 Locus

Frontiers in Plant Science, 2020
The genetic control of plant architecture in crops is critical for agriculture and understanding morphological evolution. This study showed that an open reading frame (ORF) of the rice domestication gene PROG1 appeared 3.4–3.9 million years ago (Mya ...
Liyu Huang, Hui Liu, Hui Liu, Junjie Wu, Ruoping Zhao, Yanxia Li, Getachew Melaku, Getachew Melaku, Shilai Zhang, Guangfu Huang, Yachong Bao, Min Ning, Benjia Chen, Yurui Gong, Qingyi Hu, Jing Zhang, Yesheng Zhang, Yesheng Zhang   +17 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

STay tunEd: mutational analysis of the HvSTE1 gene in barley provides insight into the balance between semi-dwarfism and maintenance of grain size in brassinosteroid biosynthesis-dependent manner

Frontiers in Plant Science
Brassinosteroids (BRs) are steroid phytohormones which regulate various physiological and developmental processes throughout plant life cycle. The BR biosynthesis has been studied mainly in the dicot model species - Arabidopsis thaliana.
Karolina Zolkiewicz, Jana Oklestkova, Beata Chmielewska, Damian Gruszka   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional Characterisation of GmGASA1-like Gene in Glycine max (L.) Merr.: Overexpression Promotes Growth, Development and Stress Responses

Life
The presence of Gibberellic Acid-Stimulated Arabidopsis, GASA, gene family has been reported in many important plants, playing roles in various aspects of plant biology but little has been uncovered in soybeans.
Mohamed A. S. Khalifa, Qi Zhang, Yeyao Du, Nooral Amin, Baozhu Dong, Piwu Wang   +5 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Contributions of Adaptive Plant Architecture to Transgressive Salinity Tolerance in Recombinant Inbred Lines of Rice: Molecular Mechanisms Based on Transcriptional Networks

Frontiers in Genetics, 2020
Genetic novelties are important nucleators of adaptive speciation. Transgressive segregation is a major mechanism that creates genetic novelties with morphological and developmental attributes that confer adaptive advantages in certain environments. This
Isaiah Catalino M. Pabuayon, Ai Kitazumi, Glenn B. Gregorio, Rakesh Kumar Singh, Benildo G. de los Reyes   +4 more
doaj   +1 more source

How meristems shape plant architecture in cereals.

Meristems are major determinants of plant architecture, plant diversification and acclimation to environmental stresses. Moreover, meristems play also a major role during crop domestication and are fundamentally important for the productivity of crop ...
Thirulogachandar, Venkatasubbu, Zhou, Yaping, Maika, Jan, Zhao, Shuangshuang, Stahl, Yvonne, Raissig, Michael, Schnittger, Arp, van der Linde, Karina, Dresselhaus, Thomas, Timmermans, Marja, Balboni, Martina, Mondragon, Cecilia Lara, von Korff, Maria, Jiang, Guojing, Schnurbusch, Thorsten, Ku, Jia-Chi, Simon, Rüdiger, Berg, Lea, Dolata, Anika, Hochholdinger, Frank, Huang, Yongyu   +20 more
core   +1 more source