Results 51 to 60 of about 610,016 (308)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Nature Communications, 2019 During innate immune responses, plant cells secrete proteases into apoplastic spaces where they contribute to pathogen resistance. Here Wang et al. show that the Arabidopsis SAP1 and SAP2 proteases cleave the bacterial MucD protein to inhibit growth of ...
Yiming Wang +8 more
doaj +1 more source
COBRA: a new European research project for organic plant breeding [PDF]
, 2013 Development of organic plant breeding and seed production will have a valuable impact on organic plant production. Breeding of plant material adapted for organic agriculture is crucial in order to cope with stresses such as climate change, weeds and seed
Baresel, P. +8 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Regeneration and transformation of Polish cultivars of potato
Acta Societatis Botanicorum Poloniae, 2014 The article presents the results of regeneration and transformation experiments of 12 Polish cultivars of potato. The cultivars Brda, Bzura, Elipsa and Irga regenerated the highest number of shoots from leaf explants (60% to 100% of explants regenerated ...
Anna Nadolska-Orczyk +4 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
ScientificaThe experiment was conducted using an alpha lattice design with two replications for each genotype, comprising 20 maize hybrids obtained from CIMMYT and NMRP, including two check varieties.
Ram Chandra Bhatta +4 more
doaj +1 more source
Future breeding for organic and low-input agriculture: integrating values and modern breeding tools for improving robustness [PDF]
, 2010 Organic production and also the attention for plant breeding for organic agriculture is still increasing in Europe. The question often raised is how much does plant breeding for the organic sector differ from modern plant breeding and does a ban on GMO ...
Lammerts van Bueren, E.T.
core +1 more source
Changing Paradigms in Plant Breeding [PDF]
Plant Physiology, 2001 The origin of plant breeding traces back to the dawn of agriculture and the domestication of plants, when nomadic man first became a settler. This started in those regions of the world where plants suitable for domestication, such as large grain grasses, grew in the wild.
Koornneef, M., Stam, P.
openaire +2 more sources