Results 251 to 260 of about 15,453,085 (385)

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Characterizing the effect of impeller design in plant cell fermentations using CFD modeling. [PDF]

Sci Rep
Manickavasagam VM, Anupindi K, Bhatt N, Srivastava S.   +3 more
europepmc   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Protocol for probing candidate effector activity using the Prf-based plant cell death phenotype. [PDF]

STAR Protoc
Liu J, Irigoyen S, Mandadi KK.
europepmc   +1 more source

Editorial: Plant cell endomembrane dynamics and specialization. [PDF]

Front Plant Sci, 2023
Rodriguez-Furlan C, Norambuena L, Larson ER.   +2 more
europepmc   +1 more source

The mobility of enzymes, especially diastases, to penetrate the membranes of plant cells [PDF]

, 1938

openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Back to the Wastes: The Potential of Agri-Food Residues for Extracting Valuable Plant Cell Wall Polysaccharides. [PDF]

Int J Mol Sci
Saez-Aguayo S, Sanhueza D, Fuenzalida P, Covarrubias MP, Handford M, Herrera R, Moya-León MA.   +6 more
europepmc   +1 more source

The evolving definition of plant cell type. [PDF]

Front Plant Sci, 2023
Amini S, Doyle JJ, Libault M.
europepmc   +1 more source

Photic excitation and phototropism in single plant cells [PDF]

, 1937

openalex   +1 more source