Results 91 to 100 of about 3,927,718 (319)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Structural and Biochemical Properties of Duckweed Surface Cuticle

Frontiers in Chemistry, 2018
The plant cuticle, which consists of cutin and waxes, forms a hydrophobic coating covering the aerial surfaces of all plants. It acts as an interface between plants and their surrounding environment whilst also protecting them against biotic and abiotic ...
Nikolai Borisjuk, Anton A. Peterson, Jiyang Lv, Guorun Qu, Qian Luo, Lei Shi, Guimin Chen, Olena Kishchenko, Yuzhen Zhou, Jianxin Shi   +9 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Adaptation of cuticle metabolism to abiotic stress in plants

Crop and Environment
The cuticle, primarily composed of waxes and cutin polyesters, is a hydrophobic layer that covers the surfaces of plant tissues, evolving as physiological and biochemical adaptations to diverse environments.
Peimin Zhao, Qianqian Li, Yang Lei, Jitao Zou, Qiang Li   +4 more
doaj   +1 more source

Nectaries and reproductive biology of croton sarcopetalus (euphorbiaceae) [PDF]

, 2001
Flower morphology, nectary structure, nectar chemical composition, breeding system, floral visitors and pollination were analysed in Croton sarcopetalus, a diclinous-monoecious shrub from Argentina.
Bernardello, Gabriel Luis Mario, Freitas, Leandro, Galetto, Leonardo, Paoli, Adelita   +3 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Microbes Attaching to Endoparasitic Phytonematodes in Soil Trigger Plant Defense Upon Root Penetration by the Nematode

Frontiers in Plant Science, 2020
Root-knot nematodes (Meloidogyne spp.) are among the most aggressive phytonematodes. While moving through soil to reach the roots of their host, specific microbes attach to the cuticle of the infective second-stage juveniles (J2).
Olivera Topalović, Sandra Bredenbruch, A. Sylvia S. Schleker, Holger Heuer   +3 more
doaj   +1 more source

Evidence for diversifying selection of genetic regions of encoding putative collagen-like host-adhesive fibers in Pasteuria penetrans [PDF]

, 2019
© FEMS 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided ...
Anderson, Andrews, Arohi Srivastava, Arslan, Atibalentja, Aziz, Carver, Charles, Cohan, Colson, Davies, Davies, Davies, Davies, Davies, Davies, Degnan, DePristo, Duan, Dutta, Eardly, Espanol, Felsenstein, Filée, Gascuel, Giblin-Davis, Giblin-Davis, Huynen, Jones, Kanehisa, Kaufman, Keith G Davies, Kumar, Legendre, Luijckx, Luijckx, Maddison, Mauchline, McElroy, Metchnikoff, Mohan, Mohan, Mouton, Murtagh, Noel, Philippe, R Developement Core Team, Radó-Trilla, Rajendhran, Romero, Rutherford, Sayre, Sayre, Schouls, Sharad Mohan, Sharma, Stackebrandt, Starr, Steichen, Stirling, Stirling, Sturhan, Sylvestre, Sylvestre, Tamura, Tim H Mauchline, Todd, Wiedenbeck, Woese, Yap, Zilversmit   +70 more
core   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Phyllosphere microbiology with special reference to diversity and plant genotype [PDF]

, 2008
The phyllosphere represents the habitat provided by the aboveground parts of plants, and on a global scale supports a large and complex microbial community.
Adams, Andrews, Arnold, Arnold, Asins, Beattie, Beattie, Becker, Bernstein, Blakeman, Brandl, Brandl, Bunster, Corpe, Correa, Davis, de Jager, Diem, Dik, Dingman, Elvira-Recuenco, Fourtouni, Freiberg, Gal, Glickmann, Glushakova, Gourion, Greenberg, Hirano, Hirano, Hirano, Hirano, Hutchison, Idris, Inacio, Ishimaru, Jackson, Jacques, Jacques, Kadivar, Kinkel, Kinkel, Kinkel, Kinkel, Klerks, Lacey, Lamb, Lambais, Larran, Last, Leben, Legard, Leveau, Lighthart, Lindemann, Lindemann, Lindow, Lindow, Manceau, Mansvelt, Manulis, Mariano, Mechaber, Mew, Mew, Miller, Miyamoto, Monier, Morris, Morris, Morris, Morris, Morris, Morris, Murty, Oliveira, O’Brien, O’Callaghan, Papen, Pillay, Preston, Quigley, Ramette, Rasche, Rasche, Rasche, Reiter, Romantschuck, Schreiber, Schweitzer, Sessitsch, Sessitsch, Shepherd, Singh, Stapleton, Sundin, Sundin, Surico, Suslow, Swift, ten Hoopen, Thompson, Upper, Van Aken, Venette, Wagner, Whipps, Wildman, Wilson, Wulff, Yang, Zak   +111 more
core   +1 more source