Results 81 to 90 of about 2,510,143 (277)
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
, 2021 The cuticle is a lipidic structure covering plant aerial organs, providing mechanical rigidity and acting as a protective barrier. It contains the cutin polyester and waxes, which are derived from very-long-chain fatty acids.
Voloshina, Mariia
core
GPAT2 is required for root cap cuticle formation in young Arabidopsis seedlings
Cell ReportsSummary: During seedling establishment, a cuticle protects the root cap until the outer embryonic cell layer is shed. In Arabidopsis, the root cap cuticle of primary roots has a distinct composition that includes ester-bound unsubstituted very-long-chain
Alice Berhin +3 more
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Dynamic changes to the plant cuticle include the production of volatile cuticular wax-derived compounds. [PDF]
Proc Natl Acad Sci U S A, 2023 Chen JY +3 more
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Cuticle Micromorphology of Falcatifolium de Laubenfels (Podocarpaceae).
, 1992 Cuticle micromorphology of leaves from all five species of the Southern Hemisphere conifer genus Falcatifolium de Laubenfels (Podocarpaceaew) as studied with scanninge lectron microscopy. Both herbarium and preserved specimens were examined and showed no
Ko, H., Stockey, R.A., Woltz, P.
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Genetics and Molecular Biology, 2017 The naturally occurring wild barley mutant eibi1/hvabcg31 suffers from severe water loss due to the permeable leaf cuticle. Eibi1/HvABCG31 encodes a full ATP-binding cassette (ABC) transporter, HvABCG31, playing a role in cutin deposition in the ...
Qin Zhou +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source