Results 101 to 110 of about 3,927,718 (319)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

How does the nectar of stomata-free nectaries cross the cuticle?

Acta Botânica Brasílica
In many glandular structures, departure from the cell is only one step in the process of exudate release to the plant surface. Here the set of events that lead nectar to the external environment is presented and discussed mainly for stomata-free ...
Elder Antônio Sousa Paiva
doaj   +1 more source

New record of the sea anemone Kadosactis antarctica (Carlgren, 1928): re-description of an Antarctic deep-sea sea anemone, and a discussion of its generic and familial placement [PDF]

, 2005
Sagartiogeton antarcticus Carlgren, 1928 is an Antarctic deep-sea species of sea anemone only known from its holotype. The species has been assigned to the genera Sagartiogeton and Kadosactis, and is currently placed within the family Kadosactidae ...
López González, Pablo José, Rodríguez Díaz, Estefanía   +1 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Morphology and DNA sequence data reveal the presence of Globodera ellingtonae in the Andean region [PDF]

, 2014
Potato cyst nematodes, G. rostochiensis and G. pallida, are the most economically important nematode pests of potatoes worldwide and are subject to strict quarantine regulations in many countries. Globodera ellingtonae was recently described from Oregon (
Doucet, Marcelo Edmundo, Franco Ponce, Javier, Gardenal, Cristina Noemi, Lax, Paola, Rondan Dueñas, Juan   +4 more
core  

In vivo chemical and structural analysis of plant cuticular waxes using stimulated Raman scattering microscopy. [PDF]

, 2015
The cuticle is a ubiquitous, predominantly waxy layer on the aerial parts of higher plants that fulfils a number of essential physiological roles, including regulating evapotranspiration, light reflection, and heat tolerance, control of development, and ...
Lind, R, Littlejohn, GR, Love, J, Mansfield, JC, Moger, J, Parker, D, Perfect, S, Seymour, M, Smirnoff, N   +8 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

GPAT2 is required for root cap cuticle formation in young Arabidopsis seedlings

Cell Reports
Summary: During seedling establishment, a cuticle protects the root cap until the outer embryonic cell layer is shed. In Arabidopsis, the root cap cuticle of primary roots has a distinct composition that includes ester-bound unsubstituted very-long-chain
Alice Berhin, Aurore Guerault, Damien De Bellis, Christiane Nawrath   +3 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source