Results 91 to 100 of about 720,063 (299)

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Isolation And Characterization Of Phenylalanine Ammonia Lyase (Pal) And Other Defence Response Genes From Oil Palm (Elaies Guineensis Jacq.) [PDF]

, 2002
Enhanced disease resistance and plant defense response against pathogen attack and environmental stresses have always been important targets of plant biotechnology. The activation of the defense response requires the recognition of an elicitor and the
Hwang, Siaw San
core  

Arabidopsis defense against Botrytis cinerea : chronology and regulation deciphered by high-resolution temporal transcriptomic analysis [PDF]

, 2012
Transcriptional reprogramming forms a major part of a plant’s response to pathogen infection. Many individual components and pathways operating during plant defense have been identified, but our knowledge of how these different components interact is ...
Atwell, Susanna, Baxter, Laura, Beynon, Jim, Borgwardt, Karsten M., Breeze, Emily, Buchanan-Wollaston, Vicky, Cooke, Emma J., Denby, Katherine J., Finkenstädt, Bärbel, Hickman, Richard J., Hill, Claire, Jenkins, Dafyd J., Kiddle, Steven J., Kim, Youn-sung, Kliebenstein, Daniel James, Legaie, Roxane, Madhou, Priyadharshini, McHattie, Stuart, Mead, A., Moore, Jonathan D., Ott, Sascha, Penfold, Christopher A., Rand, D. A., Rhodes, Johanna, Stegle, Oliver, Tabrett, Alex, Wild, David L., Windram, Oliver P., Zhang, Cunjin   +28 more
core   +3 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Role of Silicon on Plant–Pathogen Interactions

Frontiers in Plant Science, 2017
Although silicon (Si) is not recognized as an essential element for general higher plants, it has beneficial effects on the growth and production of a wide range of plant species.
Min Wang, Limin Gao, Suyue Dong, Yuming Sun, Qirong Shen, Shiwei Guo   +5 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Insights into the plant response to nematode invasion and modulation of host defense by plant parasitic nematode

Frontiers in Microbiology
Plant pathogens cause diseases by suppressing plant immune response and interacting with plant cells. Investigating these interactions assists in decoding the molecular strategies the pathogen uses to overcome plant immunity.
Xiaolong Chen, Fuqiang Li, Ding Wang, Liqun Cai   +3 more
doaj   +1 more source

Chitinases—Potential Candidates for Enhanced Plant Resistance towards Fungal Pathogens

Agriculture, 2018
Crop cultivation is crucial for the existence of human beings, as it fulfills our nutritional requirements. Crops and other plants are always at a high risk of being attacked by phytopathogens, especially pathogenic fungi.
Manish Kumar, Amandeep Brar, Monika Yadav, Aakash Chawade, V. Vivekanand, Nidhi Pareek   +5 more
doaj   +1 more source

Trichoderma atroviride P1 Colonization of Tomato Plants Enhances Both Direct and Indirect Defense Barriers Against Insects [PDF]

, 2019
Numerous microbial root symbionts are known to induce different levels of enhanced plant protection against a variety of pathogens. However, more recent studies have demonstrated that beneficial microbes are able to induce plant systemic resistance that ...
CASCONE, PASQUALE, Coppola M, Di Lelio I, Digilio MC, Guerrieri E, Lorito M, Pennacchio F, Rao R, Woo SL   +8 more
core   +2 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source