Results 81 to 90 of about 4,341,163 (257)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Plant Diversity Affects Rodents’ Selection of Different-Sized Seeds

Environmental changes may affect animal hoarding behavior through changes to plant diversity. Food hoarding behavior in small mammals can affect the seed dispersal process and thus the regeneration of the plant population.
Jiming Cheng, Chao Zhang, Yonghong Luo, Jiahui Liu, Yingqun Feng, Ningli Wang, Xinyue Chen, Xingfu Yan   +7 more
core   +1 more source

Plastome comparison and phylogenomic analysis of threatened wild Egyptian Capparis taxa

BMC Genomics
Background Capparis is one of the largest genera in the Capparaceae family, it is currently classified as comprising threatened wild plants in Egypt. The taxonomy of Capparis remains ambiguous due to complex classifications, overlapping morphological ...
Norhan Amar, Heba A. M. AbdAlla, Qing-Feng Wang, Mohamed Abd. S. El Zayat, Hager R. Belal, Sheng-Wei Wang, Tao Wan, Mohamed Hamdy Amar, Jun-Nan Wan   +8 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Rapid transfer of photosynthetic carbon through the plant-soil system in differently managed species-rich grasslands [PDF]

, 2011
Plant-soil interactions are central to short-term carbon (C) cycling through the rapid transfer of recently assimilated C from plant roots to soil biota. In grassland ecosystems, changes in C cycling are likely to be influenced by land use and management
Bardgett, Richard, Quirk, Helen, Oakley, Simon, Ostle, Nick, De Deyn, Gerlinde   +4 more
core   +6 more sources

Author Correction: A mycorrhizae-like gene regulates stem cell and gametophore development in mosses

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Shuanghua Wang, Yanlong Guan, Qia Wang, Jinjie Zhao, Guiling Sun, Xiangyang Hu, Mark P. Running, Hang Sun, Jinling Huang   +8 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Modelling Urban Plant Diversity Along Environmental, Edaphic, and Climatic Gradients

Urbanization imposes complex environmental gradients that threaten plant diversity and urban ecosystem integrity. Understanding the multifactorial drivers that govern species distribution in urban contexts is essential for biodiversity conservation and ...
Ecir Uğur Küçüksille, Tuba Gül Doğan, Engin Eroğlu, Tarık Gedik, Mustafa İsa Doğan   +4 more
core   +1 more source