Results 91 to 100 of about 4,341,163 (257)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Plant Diversity and Ecological Indices of Naturally Established Native Vegetation in Permanent Grassy Strips of Fruit Orchards in Southern Romania

This paper assesses the complexity and diversity of vegetation in grassy strips with spontaneous plants between tree rows in three fruit orchards (plum, cherry, apple) in Dolj County, Romania, using structural and biodiversity indices.
Florin Daniel Stamin, Nicolae Constantin Gheorghiu, Daniel Răduțoiu, Sina Cosmulescu   +3 more
core   +1 more source

Ethnomedicinal plants and traditional healing practices of indigenous communities in Dan Sub-district, Kap Choeng District, Surin Province, Thailand

Journal of Ethnobiology and Ethnomedicine
Background Medicinal plants constitute a vital component of healthcare systems, cultural identity, and community resilience in many rural societies, particularly in northeastern Thailand.
Piyaporn Saensouk, Surapon Saensouk, Bin Huang, Wei Shen, Khamfa Chanthavongsa, Auemporn Junsongduang, Phiphat Sonthongphithak, Tammanoon Jitpromma   +7 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The Diversity and Gradient of Sand-Dune Vegetation at Kasatura Bay: A Plant Biodiversity Hotspot in European Türkiye

The Kasatura Bay region is one of Türkiye’s Important Plant Areas and plant biodiversity hotspots. In this study, the diversity and gradient of the sand-dune vegetation in Kasatura Bay were studied. Vegetation sampling was carried out by using
Asuman Efe, Dilek Oral, Ali Kavgacı
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Radiating diversification and niche conservatism jointly shape the inverse latitudinal diversity gradient of Potentilla L. (Rosaceae)

BMC Plant Biology
Background The latitudinal diversity gradient (LDG), characterized by an increase in species richness from the poles to the equator, is one of the most pervasive biological patterns. However, inverse LDGs, in which species richness peaks in extratropical
Tiantian Xue, Tao Feng, Yunfen Liang, Xudong Yang, Fei Qin, Jianghong Yu, Steven B. Janssens, Shengxiang Yu   +7 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Diversity Patterns of Different Life Forms of Plants along an Elevational Gradient in Crete, Greece

, 2019
Elevational gradients provide a unique opportunity to explore species responses to changing environmental conditions. Here, we focus on an elevational gradient in Crete, a climate-vulnerable Mediterranean plant biodiversity hotspot and explore the ...
Maria Psaralexi, Stefanos P. Sgardelis, Maria Lazarina, Athanasios Charalampopoulos, Athanasios S. Kallimanis, Danai-Eleni Michailidou, Nikos Krigas   +6 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source