Results 141 to 150 of about 327,235 (306)

Wind farms reduce grassland plant community diversity and lead to plant community convergence

BMC Ecology and Evolution
Climate warming has become a hot issue of common concern all over the world, and wind energy has become an important clean energy source. Wind farms, usually built in wild lands like grassland, may cause damage to the initial ecosystem and biodiversity ...
Xuancheng Zhao, Fengshi Li, Yuan Yuan, Guna Ari, Yongzhi Yan, Qing Zhang, Aruhan Olhnuud, Pengtao Liu   +7 more
doaj   +1 more source

TRIM47 Regulates Energy Metabolism via Glycolytic Reprogramming to Drive Hepatocellular Carcinoma Progression and Represents an Efficient Therapeutic Target

Advanced Science, EarlyView.
This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun, Yihang Yuan, Qian Qiu, Kexuan Tan, Xutong Li, Haotian Li, Luyang Kang, Yuting Gu, Ziheng Zhang, Jiayu He, Jiali Li, Junjie Lin, Zihan Xie, Kexing Han, Jiabin Li, Yang Zhang, Ting Wu, Yufeng Gao   +17 more
wiley   +1 more source

Brandt's vole (Lasiopodomys brandtii) affects the dominant position of three gramineous species by altering defense traits and interspecific competition

Ecology and Evolution
Rodents can cause considerable changes in plant community composition. However, relationships between shifts in species dominance and plant functional traits caused by rodents have seldom been investigated, especially for belowground functional traits ...
Yanjin Xie, Yongle Hua, Jiading Zhang, Wanhong Wei, Baofa Yin   +4 more
doaj   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

Are Plant Functional Types Fit for Purpose?

Geophysical Research Letters
For over 40 years, Plant Functional Types (PFTs) have been used to discretize the ∼400,000 species of terrestrial plants into “similar” classes. Within Earth System Models (ESMs), PFTs simplify terrestrial biosphere modeling in combination with soil ...
Jon Cranko Page, Gab Abramowitz, Martin. G. De Kauwe, Andy J. Pitman   +3 more
doaj   +1 more source

Phylogenetic imputation of plant functional trait databases

Ecography, 2013
Continental‐scale maps of plant functional diversity are a fundamental piece of data of interest to ecosystem modelers and ecologists, yet such maps have been exceedingly hard to generate. The large effort to compile global plant functional trait databases largely for the purpose of mapping and analyzing the spatial distribution of function has ...
openaire   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Plant economics spectrum governs leaf nitrogen and phosphorus resorption in subtropical transitional forests

BMC Plant Biology
Background Leaf nitrogen (N) and phosphorus (P) resorption is a fundamental adaptation strategy for plant nutrient conservation. However, the relative roles that environmental factors and plant functional traits play in regulating N and P resorption ...
Boyu Ma, Jielin Ge, Changming Zhao, Wenting Xu, Kai Xu, Zongqiang Xie   +5 more
doaj   +1 more source

Response of Plant Leaf Traits to Environmental Factors in Climax Communities at Varying Latitudes in Karst Regions

Plants
Exploring the changes in plant functional traits and their relationship with the environment in karst climax communities across different latitudes can enhance our understanding of how these communities respond to environmental gradients.
Gang Xie, Yang Wang, Zhifeng Chen, Yangyang Ji, Yao Lu, Yi Liang, Ruiyu Zhou, Juan Tao   +7 more
doaj   +1 more source