Results 121 to 130 of about 2,126,463 (312)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

The Effect of Bastard Trenching on the Soil and on Plant Growth [PDF]

open access: green, 1913
Spencer Umfreville Pickering   +1 more
openalex   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Dynamics of Labor Demand: Evidence from Plant-level Observations and Aggregate Implications [PDF]

open access: yes
This paper studies the dynamics of labor demand at the plant and aggregate levels. The correlation of hours and employment growth is negative at the plant level and positive in aggregate time series. Further, hours and employment growth are about equally
John C. Haltiwanger   +2 more
core  

Collaborative weed modelling with Universal Simulator [PDF]

open access: yes, 2010
Universal Simulator is • open-source • modular • extendible • re-usable Universal Simulator includes • the INTERCOM model of plant growh • the Conductance model of plant growth • an annual weed demographic model • an insect demographic model ...
Holst, Niels
core  

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

Black tea preserves intestinal homeostasis through balancing barriers and microbiota in mice

open access: yesFrontiers in Nutrition
IntroductionBlack tea, a beverage consumed worldwide, possesses favorable effects on gastrointestinal tract, including nourishing stomach and promoting digestion. Nevertheless, its specific effects on intestinal homeostasis remains inconclusive.MethodsWe
Yuxuan Shi   +9 more
doaj   +1 more source

Bagging Treatment Influences Production of C6 Aldehydes and Biosynthesis-Related Gene Expression in Peach Fruit Skin

open access: yesMolecules, 2014
Bagging is a useful method to improve fruit quality by altering its exposure to light, whereas its effect on fruit volatiles production is inconsistent, and the genes responsible for the observed changes remain unknown. In the present study, single-layer
Ji-Yuan Shen   +6 more
doaj   +1 more source

Influence of Plant Growth Regulators on Somatic Embryogenesis Induction in Seriphidium herba-album [PDF]

open access: yes, 2018
Seriphidium herba-album (syn. Artemisia herba-alba) is a medicinal, aromatic, greenish-silver herb. It is used widely in folk medicine for treatment of diarrhea, abdominal cramps and in the healing of external wounds.
Abo-El-Hasan, F. M. (Fatma)   +3 more
core  

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