Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Determination of 10 Antibiotics and 53 Plant Growth Regulators in Citrus Fruits by QuEChERS Combined with Liquid Chromatography-Quadrupole/Orbitrap Mass Spectrometry. [PDF]
Xie Y +7 more
europepmc +1 more source
Impacts of plant growth regulators in strawberry plant: A review. [PDF]
Katel S +4 more
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Research Progress on the Application of Plant Growth Regulators in the Rapid Propagation of Jujube by In Vitro Culture. [PDF]
Yang B, Luo Z, Zhu X, Ji Y, Ma Q, Yan F.
europepmc +1 more source
Effects of plant growth regulators and sucrose on proliferation and quality of embryogenic tissue in Picea pungens. [PDF]
Gao F +7 more
europepmc +1 more source
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Effects of Different Plant Growth Regulators on Growth Physiology and Photosynthetic Characteristics of <i>Pinus koraiensis</i> Seedlings. [PDF]
Zhang W +9 more
europepmc +1 more source

