Results 71 to 80 of about 7,688,023 (293)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Impact of new generation plant growth regulators on fruit crops - A Review

Plant growth regulators (PGRs) are artificially synthesized substances that control growth, development, and other various physiological processes in plants.
Rodge Rahul Ramprasad, Thammali Vamshi, Gulbadan Kaur, Akshay Kumar, Rajni Rajan, Kuldeep Pandey, Tanya Singh   +6 more
core   +1 more source

Role of plant growth regulators in flower crops

, 2022
Plant growth regulators play a critical role in the integration of developmental processes. Environmental variables frequently cause inductive effects in plants by causing changes in hormone metabolism and distribution.
Ali Haidar Shah, Priyanka Thakur, Sita Ram Dhiman, Pooja Sharma   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

INFLUENCE OF THE APPLICATION OF PLANT GROWTH REGULATORS ON THE GROWTH, DEVELOPMENT AND YIELD OF COTTON

, 2022
This article analyzes the influence of plant growth regulators (biostimulator), the growth, development and yield of cotton in the conditions of irrigated lands of the Kashkadarya ...
S.Samadov Z.Ibragimov
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Effect of different water regimes and plant growth regulators on growth, physiology and yield of banana (Musa acuminata cv. Berangan) in tropical climate [PDF]

, 2018
A field investigation under tropical climate was undertaken in the research plot of the Universiti Putra Malaysia, Selangor, Malaysia to study the effects of exogenous application of plant growth regulators on growth performance, physiology changes and ...
Juraimi, Abdul Shukor, Mohd Din, Siti Norliza, Zakaria, Md Aiman Takrim, Jaafar, Hawa ZE, Sakimin, Siti Zaharah, Ali Baghdadi, Ramlan, Mohd Fauzi, Baghdadi, Ali, Md Zakaria, Siti Din, Hawa Jaafar, Siti Sakimin, Mohd Ramlan   +12 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source