Results 141 to 150 of about 14,032,843 (262)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
[Publications of the Faculty of the Section of Plant Pathology]
, 1911 Compilation of articles from various journals, published from 1911-1958, written by faculty of the Section of Plant PathologyTitle and numbering supplied by bindery.Vol. 1-14 called also: no. 1-565.Compilation of articles from various journals, published
University of Minnesota. Section of Plant Pathology.
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Modulation of plant immunity by atmospheric CO2 [PDF]
, 2016 The continuously increasing CO2 levels in the atmosphere is considered to be core among climate changes and is expected to affect plant diseases in the future, posing a new challenge for future strategies in plant protection.
Sub Plant-Microbe Interactions +2 more
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The workshop on gender and plant health: The power of interdisciplinary research
Gender and Plant Health has often been seen as a very unusual combination, since two disciplines have a different epistemological orientation, use different languages, and have limited experience in working together.
Plant Health Initiative
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Northern Territory Mental Health Service Strategic Plan 2015 - 2021
, 2015 The Plan sets priorities to support and increase the capacity of the mental health system to meet the needs of mental health consumers in the Northern ...
Department of Health
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2015 This toolkit has been developed for use by consumer representatives participating in any NT Health (Department of Health, Top End Health Service and Central Australia Health Service) activities (i.e.
Department of Health
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