Results 41 to 50 of about 2,893,681 (260)

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono   +7 more
wiley   +1 more source

Conserved effector families render Phytophthora species vulnerable to recognition by NLR receptors in nonhost plants

open access: yesNature Communications
NLR receptor is suggested as a component of plant nonhost resistance (NHR). However, the evolutionary process of how plants develop receptors for recognizing broad-spectrum pathogens is still elusive. Here, we observe that multiple RxLR effector families
Soohyun Oh   +5 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

The role of effectors in nonhost resistance to filamentous plant pathogens [PDF]

open access: yes, 2014
In nature, most plants are resistant to a wide range of phytopathogens. However, mechanisms contributing to this so-called nonhost resistance (NHR) are poorly understood.
McLellan, Hazel   +11 more
core   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Recent advances in plant immunity: recognition, signaling, response, and evolution

open access: yes, 2013
Innate immune system is employed by plants to defend against phytopathogenic microbes through specific perception of non-self molecules and subsequent initiation of resistance responses.
S. Hou, D. Wu, C. Zhang, Y. Yang
core   +1 more source

Ubiquitination of Receptorsomes, Frontline of Plant Immunity

open access: yes, 2022
Sessile plants are constantly exposed to myriads of unfavorable invading organisms with different lifestyles. To survive, plants have evolved plasma membrane-resident pattern recognition receptors (PRRs) and intracellular nucleotide-binding domain ...
Jing Liu   +4 more
core   +1 more source

Molecular Mechanism & Structure—Zooming in on Plant Immunity

open access: yes, 2021
The first of three International Society for Molecular Plant–Microbe Interactions (IS-MPMI) eSymposia was convened on 12 and 13 July 2021, with the theme “Molecular Mechanism & Structure—Zooming in on Plant Immunity”.
Rima, S.   +3 more
core   +2 more sources

A plant NLR receptor employs ABA central regulator PP2C-SnRK2 to activate antiviral immunity

open access: yesNature Communications
Defence against pathogens relies on intracellular nucleotide-binding, leucine-rich repeat immune receptors (NLRs) in plants. Hormone signaling including abscisic acid (ABA) pathways are activated by NLRs and play pivotal roles in defence against ...
Shen Huang   +12 more
doaj   +1 more source

An Arabidopsis nonhost resistance gene, IMPORTIN ALPHA 2 provides immunity against rice sheath blight pathogen, Rhizoctonia solani

open access: yesCurrent Research in Microbial Sciences, 2022
There is neither resistant rice cultivar nor any control measure against Rhizoctonia solani AG-1 IA (RS), causal of sheath blight and a major threat to global rice production. Rice is a host and Arabidopsis is a nonhost with underlying nonhost resistance
Daraksha Parween, Binod Bihari Sahu
doaj   +1 more source

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