Results 131 to 140 of about 329,766 (293)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Method for CaOx crystals isolation from plant leaves. [PDF]

MethodsX, 2022
Cerritos-Castro IT, Patrón-Soberano A, Barba de la Rosa AP.   +2 more
europepmc   +1 more source

Effects of Salinity, Planting Density and Lateral Shoot Leaves under Truss on Yield and Total Soluble Solids of Tomato Fruits Grown in Hydroponics

, 2006
Takeshi Saito, Naoya Fukuda, Shigeo Nishimura   +2 more
openalex   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A deep learning generative model approach for image synthesis of plant leaves. [PDF]

PLoS One, 2022
Benfenati A, Bolzi D, Causin P, Oberti R.   +3 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Antimicrobial Activity against Foodborne Pathogens and Antioxidant Activity of Plant Leaves Traditionally Used as Food Packaging. [PDF]

Foods, 2023
Thongphichai W, Pongkittiphan V, Laorpaksa A, Wiwatcharakornkul W, Sukrong S.   +4 more
europepmc   +1 more source

Studies on the Effect of the Relative Humidity of the Atmosphere on the Growth and Physiology of Rice Plants. X. Effect of ambient humidity on the translocation of assimilated 13C in leaves.

, 1996
Gen-ichi Hirai, Toshikatsu Okumura, Shiro TAKEUCHI, Osamu Tanaka, Hiroyoshi Chujo, Naomichi TANAKA   +5 more
openalex   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Temporary establishment of bacteria from indoor plant leaves and soil on human skin. [PDF]

Environ Microbiome, 2022
Mhuireach GÁ, Fahimipour AK, Vandegrift R, Muscarella ME, Hickey R, Bateman AC, Van Den Wymelenberg KG, Bohannan BJM.   +7 more
europepmc   +1 more source