Results 131 to 140 of about 4,348,204 (300)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Progress report - Plant Protection and Quarantine Programs.

open access: yes
Report covers fiscal year 1979.Mode of access: Internet.Supersedes: United States. Agricultural Research Service. Plant Protection Division. Annual report - U.S.
United States. Animal and Plant Health Inspection Service. Plant Protection and Quarantine Programs.
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

New Unity Movement : statement on sporting contact with South Africa

open access: yes
The New Unity Movement supports SACOS fully in its total opposition to mercenary, racist, international sporting contact with South Africa. The cancellation of the All Blacks tour is a victory for non-racial sport!
The New Unity Movement (NUM)
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Growing Translational Plant Sciences

open access: yes, 2015
The annual magazine for the Virginia Tech Translational Plant Sciences (TPS) graduate program, formerly Molecular Plant Sciences (MPS)
Translational Plant Sciences   +1 more
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Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Growing Translational Plant Sciences

open access: yes, 2016
The annual magazine for the Virginia Tech Translational Plant Sciences (TPS) graduate program, formerly Molecular Plant Sciences (MPS)
Translational Plant Sciences   +1 more
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Molecular movement in the Arabidopsis thaliana female gametophyte

open access: yes, 2019
Cellular decisions can be influenced by information communicated from neighboring cells. Communication can occur via signaling or through the direct transfer of molecules.
Gehring, Mary   +5 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

The doors of learning remain tightly shut to the majority of our youth : New Unity Movement declaration on our schools

open access: yes
The New Unity Movement addresses the issue on the high amount of school drop-outs within our communities. Questions arise and possible solutions are mentioned: What is wrong with our schools?, Poor performance and the high drop out rate?, OBE is the main
New Unity Movement
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