Results 111 to 120 of about 4,348,204 (300)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Movement of Desert Grassland Whiptails, Aspidoscelis uniparens, in a Structured Landscape

Diversity
Landscape structure can affect movement, which is influenced by foraging, thermoregulation, and predation risk. We evaluated search paths relative to landscape cover for a unisexual lizard (Aspidoscelis uniparens) whose movement is primarily motivated by
Douglas A. Eifler, Margaret C. Stanley, Darren F. Ward, Hannah Reynolds, Julia Clem, Maria A. Eifler   +5 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Unity Movement : principles and policy

A document in which the principles and policies of the Unity Movement are stated: non-collaboration, non-racialism, one nation, anti-imperialism, minimum demands, the working ...
Unity Movement
core  

A mechanosensitive ion channel controls touch-triggered stigma movement through manipulation of calcium signature in Torenia

Nature Communications
Rapid movements of plant structures triggered by mechanical force have been documented for centuries; however, how plant cells sense mechanical stimuli and generate rapid response remains unknown.
Xuan Zhou, Binghou Li, Jiahuizi Li, Yufei Sun, Ruohan Xie, Tetsuya Higashiyama, Shi Xiao, Guorong Xin, Shihao Su   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

[Publications of the Faculty of the Section of Plant Pathology]

, 1911
Compilation of articles from various journals, published from 1911-1958, written by faculty of the Section of Plant PathologyTitle and numbering supplied by bindery.Vol. 1-14 called also: no. 1-565.Compilation of articles from various journals, published
University of Minnesota. Section of Plant Pathology.
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source