Results 81 to 90 of about 130,006 (260)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Miniature External Sapflow Gauges and the Heat Ratio Method for Quantifying Plant Water Loss

Bio-Protocol, 2017
External sapflow sensors are a useful tool in plant ecology and physiology for monitoring water movement within small stems or other small plant organs.
Robert Skelton
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Comparative kinematical analyses of Venus flytrap (Dionaea muscipula) snap traps

Beilstein Journal of Nanotechnology, 2016
Although the Venus flytrap (Dionaea muscipula) can be considered as one of the most extensively investigated carnivorous plants, knowledge is still scarce about diversity of the snap-trap motion, the functionality of snap traps under varying ...
Simon Poppinga, Tim Kampowski, Amélie Metzger, Olga Speck, Thomas Speck   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Movement of Desert Grassland Whiptails, Aspidoscelis uniparens, in a Structured Landscape

Diversity
Landscape structure can affect movement, which is influenced by foraging, thermoregulation, and predation risk. We evaluated search paths relative to landscape cover for a unisexual lizard (Aspidoscelis uniparens) whose movement is primarily motivated by
Douglas A. Eifler, Margaret C. Stanley, Darren F. Ward, Hannah Reynolds, Julia Clem, Maria A. Eifler   +5 more
doaj   +1 more source

Comparative Genomics Analysis Provides New Insight Into Molecular Basis of Stomatal Movement in Kalanchoë fedtschenkoi

Frontiers in Plant Science, 2019
CO2 uptake and water loss in plants are regulated by microscopic pores on the surface of leaves, called stomata. This enablement of gas exchange by the opening and closing of stomata is one of the most essential processes in plant photosynthesis and ...
Robert C. Moseley, Gerald A. Tuskan, Gerald A. Tuskan, Xiaohan Yang, Xiaohan Yang, Xiaohan Yang   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A mechanosensitive ion channel controls touch-triggered stigma movement through manipulation of calcium signature in Torenia

Nature Communications
Rapid movements of plant structures triggered by mechanical force have been documented for centuries; however, how plant cells sense mechanical stimuli and generate rapid response remains unknown.
Xuan Zhou, Binghou Li, Jiahuizi Li, Yufei Sun, Ruohan Xie, Tetsuya Higashiyama, Shi Xiao, Guorong Xin, Shihao Su   +8 more
doaj   +1 more source

Inspirations on Virus Replication and Cell-to-Cell Movement from Studies Examining the Cytopathology Induced by Lettuce infectious yellows virus in Plant Cells

Frontiers in Plant Science, 2017
Lettuce infectious yellows virus (LIYV) is the type member of the genus Crinivirus in the family Closteroviridae. Like many other positive-strand RNA viruses, LIYV infections induce a number of cytopathic changes in plant cells, of which the two most ...
Wenjie Qiao, Vicente Medina, Bryce W. Falk   +2 more
doaj   +1 more source