Results 81 to 90 of about 156,299 (292)

Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance

Advanced Science, EarlyView.
A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou, Ke Li, Xuelan Li, Lei Yi, Zhengxiang Wang, Huan Ding, Sheng Wu, Feiyu Liu, Yuan Li, Rui Cheng, Jianliang Shen   +10 more
wiley   +1 more source

Crystal Facet‐Polysaccharide Matching in CFS‐P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity

Advanced Science, EarlyView.
Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and
Zhaohui Wang, Xiaojin Deng, Xujuan Huang, Yuhang Pan, Yao Qin, Lu Zhang, Le Xu, Tianyi Qin, Deteng Zhang, Yi Ma, Yalong Wang   +10 more
wiley   +1 more source

Arbuscular mycorrhizal fungi [PDF]

, 2005
The potential disease suppressiveness of arbuscular mycorrhizal (AM) fungi of various origins on Bipolaris sorokiniana in barley has been investigated.
Sjöberg, Johanna
core  

The role of effectors in nonhost resistance to filamentous plant pathogens [PDF]

, 2014
In nature, most plants are resistant to a wide range of phytopathogens. However, mechanisms contributing to this so-called nonhost resistance (NHR) are poorly understood.
Aghnoum, Antonovics, Arabidopsis Genome Initiative, Baxter, Bolton, Brunner, Chen, de Jonge, de Jonge, de Wit, Dean, Dong, Elmore, Fan, Fradin, Fry, Gilroy, Gladieux, Haas, Hacquard, Jafary, Jeuken, Jones, Jupe, Jupe, Kang, Karasov, Kaschani, King, Kombrink, Lapin, Lee, Levesque, Lozano-Torres, Ma, Maekawa, Meyers, Mondragon-Palomino, Monosi, Morris, Mueller, Niks, Palloix, Pavan, Pedersen, Porter, Qutob, Raffaele, Raffaele, Raffaele, Rice Genome Project, Rouxel, Ruan, Saunders, Schulze-Lefert, Schweizer, Segretin, Shabab, Shan, Shen, Shindo, Spanu, Stam, Stassen, Stassen, Stirnweis, Stukenbrock, Stukenbrock, Stuttmann, Sweigard, Sørensen, Tian, Tosa, Uma, van Schie, Vega-Arreguín, Vogel, Wawra, Win, Wulff, Zellerhoff, Zhang, Zheng, Zipfel   +83 more
core   +5 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Chemosensitization of plant pathogenic fungi to agricultural fungicides.

Frontiers in Microbiology, 2012
A common consequence of using agricultural fungicides is the development of resistance by fungal pathogens, which undermines reliability of fungicidal effectiveness.
Vitaly eDzhavakhiya, Larisa eShcherbakova, Yulia eSemina, Natalia eZhemchuzhina, Bruce eCampbell   +4 more
doaj   +1 more source

A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside

Advanced Science, EarlyView.
(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin, Zijian Yan, Jiayi Chen, Xiaochao Wang, Ruibin Lin, Yunqi Fu, Zhaoying Lv, Bohui Wu, Xuewei Cao, Renjian Xie, Ming Dong, Chenxiao Zheng, Li Ren   +12 more
wiley   +1 more source

Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System

Advanced Science, EarlyView.
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei, Wei Liu, Bili Cao, Dan Zhao, Chengqiang Wang, Xin Hou, Tangyuan Ning, Biao Gong   +7 more
wiley   +1 more source

Linking Plant Metabolomics with Fungal Functional Dynamics Reveals a Noncanonical S‐R‐C Adaptive Trajectory

Advanced Science, EarlyView.
Using field‐based holo‐omics, we demonstrate that developmental shifts in sorghum leaf metabolomes drive a noncanonical fungal succession from stress tolerators (S) through ruderals (R) to competitors (C). Antifungal metabolites in young leaves select for S strategists with expanded genomes, transient maltose pulses during flowering favor fast‐growing ...
Peilin Chen, John W. Taylor, Cheng Gao
wiley   +1 more source

Science: Pathogenic fungi exploit plant phosphate sensing via Nudix hydrolase effectors

Advanced Agrochem
Inorganic phosphate (Pi) homeostasis in plants is regulated by inositol pyrophosphates (PP-InsPs), which mediate phosphate starvation responses. While beneficial microorganisms, such as arbuscular mycorrhizal fungi, contribute to phosphate uptake ...
Yi-Xuan Fu, Ying Ye
doaj   +1 more source