Results 101 to 110 of about 501,563 (307)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Exploring root rot pathogens in wheat-pea rotations in Kansas [PDF]

, 2019
In 2018, over 277,000 bushels of wheat were produced on 7.7 million acres of land in Kansas alone. Based on the price of wheat by the end of 2018, this accounted for $1.44 million.
Beyer, Nick, Bruce, Myron, Davis, Mark, Mangel, Dylan, Ranabhat, Nar, Rupp, Jessica L., Smith, Nathan   +6 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Highly specific and super-sensitive Dot-ELISA and colloidal gold immunochromatographic strips for the detection of Burkholderia glumae and Burkholderia plantarii of Rice bacterial panicle blight

Crop Health
Burkholderia glumae (B. glumae) and Burkholderia plantarii (B. plantarii) are primary causal agents of rice bacterial panicle blight (RBPB) and cause substantial yield losses in rice worldwide.
Jie Dong, Weijia Mao, Cui Zhang, Bin Li, Zhiyan An, Jinyan Luo, Jianxiang Wu   +6 more
doaj   +1 more source

Burkholderia Phages and Control of Burkholderia-Associated Human, Animal, and Plant Diseases

Microorganisms
Gram-negative Burkholderia bacteria are known for causing diseases in humans, animals, and plants, and high intrinsic resistance to antibiotics. Phage therapy is a promising alternative to control multidrug-resistant bacterial pathogens. Here, we present
Bingjie Wang, Jiayi Zhang, Lei Chen, Munazza Ijaz, Ji’an Bi, Chenhao Li, Daixing Dong, Yanxin Wang, Bin Li, Jinyan Luo, Qianli An   +10 more
doaj   +1 more source

Simultaneous epidemic development of scald and net blotch on single leaf layers of a spring barley crop [PDF]

, 2005
Background and objectives Two pathogens growing on the same leaf compete for the same resources, i.e. space and plant nutrients. This may lead to density dependent disease development.
Munk, L., Pinnschmidt, H.O., Vollmer, J.H., Østergård, H.   +3 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Beneficial plant pathogens in horticulture [PDF]

, 2010
Tulipani kao i Božićna zvijezda opčinjavaju ljude svojom ljepotom već više stotina godina. Činjenica da tu ljepotu duguju patogenima, koje inače povezujemo s negativnim učincima na bilje upravo fascinira.
Malešević, Marina
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source