Results 251 to 260 of about 61,933 (277)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

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Future Scenarios for Plant Phenotyping

Annual Review of Plant Biology, 2013
With increasing demand to support and accelerate progress in breeding for novel traits, the plant research community faces the need to accurately measure increasingly large numbers of plants and plant parameters. The goal is to provide quantitative analyses of plant structure and function relevant for traits that help plants better adapt to low-input ...
Fabio, Fiorani, Ulrich, Schurr
openaire   +3 more sources

Image-based plant stornata phenotyping

2014 13th International Conference on Control Automation Robotics & Vision (ICARCV), 2014
We propose in this paper a fully automatic approach for image-based plant stornata phenotyping. Given a microscopic image of a plant leaf surface, our goal is to automatically detect stornata cells and measure their morphological and structural features, such as stornata opening length and width, and size of the guard cells.
Hamid Laga, Fahimeh Shahinnia, Delphine Fleury   +2 more
openaire   +2 more sources

Plant phenotyping: a perspective

Indian Journal of Plant Physiology, 2016
Sustainable agriculture for feeding increasing population is a foremost global challenge. The “green revolution” based crop productivity has done wonders in the past, but it has limits, and, thus, we are compelled to look for new avenues to increase productivity of important crops.
Kumud B. Mishra, Anamika Mishra, Karel Klem, null Govindjee   +3 more
openaire   +1 more source

Plant rejuvenation: from phenotypes to mechanisms

Plant Cell Reports, 2020
Plant rejuvenation refers to the reversal of the adult phase in plants and the recovery of part or all of juvenile plant characteristics. The growth and reproductive vitality of plants can be increased after rejuvenation. In recent years, research has successfully reversed the development clock in plants by certain methods; created rejuvenated plants ...
Zijie Zhang, Yuhan Sun, Yun Li
openaire   +2 more sources

3D Phenotyping of Plants

2020
In recent years, there has been significant progress in computer vision based plant phenotyping technologies. Due to their non-invasive and non-contact properties, imaging techniques are becoming state of the art in automated plant phenotyping analysis. There are several aspects of phenotyping, including plant growth, organ classification and tracking,
Ayan Chaudhury, John L. Barron
openaire   +1 more source

Ecological limits to plant phenotypic plasticity

New Phytologist, 2007
ContentsSummary749I.Phenotypic plasticity: if so good, why so little?750II.Ecological constraints caused by abiotic factors751III.Ecological constraints caused by biotic factors753IV.Ecological costs: influence of plasticity on species interactions755V.Plasticity and global change757VI.Concluding ...
Fernando, Valladares, Ernesto, Gianoli, José M, Gómez   +2 more
openaire   +2 more sources