Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Population Ecology of Thelymitra matthewsii Cheeseman Orchidaceae, in Northern New Zealand
, 2008 The terrestrial orchid Thelymitra matthewsii Cheeseman, uncommon in New Zealand, was studied to increase knowledge of the species life cycle, morphology and ecology. Results will enhance future conservation management for the species.
Fraser, Elizabeth Anne
core
How sexual reproduction affects the population biology of Phytophthora infestans [PDF]
, 2012 Phytophthora infestans is a rapidly evolving and highly adaptable pathogen. It is the cause of late blight, one of the most devastating diseases in potato production. Depending on whether both mating types are present or not, P.
Sjöholm, Lina
core
Plant-mediated effects in the Brassicaceae on the performance and behaviour of parasitoids
, 2009 Direct and indirect plant defences are well studied, particularly in the Brassicaceae. Glucosinolates (GS) are secondary plant compounds characteristic in this plant family. They play an important role in defence against herbivores and pathogens.
Gols, R., Harvey, J.A.
core +1 more source
Phylogenetic and functional distinctiveness explain alien plant population responses to competition. [PDF]
Proc Biol Sci, 2020 Levin SC +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Plant population and soil origin effects on rhizosphere nematode community composition of a range-expanding plant species and a native congener. [PDF]
Oecologia, 2020 Wilschut RA +4 more
europepmc +1 more source
Population Biology of Plant Pathogens: The Synthesis of Plant Disease Epidemiology and Population Genetics [PDF]
Plant Disease, 2003 Michael G, Milgroom, Tobin L, Peever
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source