FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Effect of different formulations of heparin analogues on radiotherapy skin markers: A cross-sectional study. [PDF]
Medicine (Baltimore)Yuasa M, Kurosaki H.
europepmc +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Defining the Safety and Efficacy of Cannabis for Chronic Pain: Novel Approaches and Reframing Objectives. [PDF]
Ann Intern MedCooper ZD.
europepmc +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Differential efficacy and anti-inflammatory mechanisms of Bailing Preparations versus Huangkui Capsules combined with SGLT-2 inhibitors for diabetic kidney disease: a network meta-analysis and GRADE assessment. [PDF]
Front PharmacolLi X, Yuan X, Wu Z.
europepmc +1 more source
Phytotherapy in Community Pharmacy: Legal Aspects, Uses, and Interactions. [PDF]
Farm ComunitariosBusto Domínguez I +5 more
europepmc +1 more source
Plant-derived nanocarriers & nanostructures for barrier-defined translation: a comprehensive review of mechanisms, targets, and translation. [PDF]
J NanobiotechnologyLv L, Yu Y, Liu J, Wang B, Li X, Li J.
europepmc +1 more source
<i>Annona muricata</i> (Soursop) and Hematopoiesis: Ethnomedicinal Insights, Immunomodulatory Mechanisms, and Translational Challenges. [PDF]
Antioxidants (Basel)Matano F, Patra A.
europepmc +1 more source