Results 21 to 30 of about 61,358 (214)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Intercropping Between Panax ginseng and Arisaema amurense Improves Ginseng Quality by Improving Soil Properties and Microbial Communities

Horticulturae
The imbalance in soil microcosm systems caused by the long-term monoculture of ginseng is the main cause of continuous cropping disorder in ginseng, an important factor limiting the development of the ginseng industry.
Bochen Lv, Hai Sun, Weiyu Cao, Jiapeng Zhu, Hao Liang, Hongjie Long, Yanmei Cui, Cai Shao, Yayu Zhang   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Metabolomics combined with physiology and transcriptomics reveals key metabolic pathway responses in ginseng roots to nitrogen and potassium deficiency

Plant Stress
Nitrogen (N) and potassium (K) are essential macronutrients for plant growth and development; however, the molecular mechanisms underlying their synergistic regulation of secondary metabolism in medicinal plants remain elusive.
Weiyu Cao, Hai Sun, Cai Shao, Yue Wang, Jiapeng Zhu, Hongjie Long, Xiaomeng Geng, Yanmei Cui, Xiangyu Hu, Changwei Sun, Yayu Zhang   +10 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Effects of Co-Application of Biochar and Phosphogypsum on Regulating the Microenvironment of Saline–Alkali Soils to Promote Safflower Growth and Quality Development

Agriculture
The utilization of saline–alkali lands and the competition between medicinal plants and grain crops are urgent issues. This study aimed to evaluate the effects of combined biochar and phosphogypsum application on soil physicochemical properties ...
Hong-Jie Long, Hai Sun, Cai Shao, Yan-Mei Cui, Wei-Yu Cao, Yue Wang, Jia-Peng Zhu, Xiao-Meng Geng, Ya-Yu Zhang   +8 more
doaj   +1 more source

Preliminary Phytochemical Analysis and Antioxidant, Antibacterial Activities of Crocus alatavicus from Kazakhstan

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2015
Phytochemical analysis of C. alatavicus revealed the presence of phenols, flavonoids, anthocyanins, carotenoids, amino acids and carbohydrates. The flavonoid, amino acids and carotenoid contents were higher in aerial part (1.50%, 7.49% and 9.78mg ...
Dariya SATYBALDIYEVA, Valentina MURSALIYEVA, Izbassar RAKHIMBAYEV, Bolatkhan ZAYADAN, Ramazan MAMMADOV   +4 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Biological characterization and in vitro fungicide screening of a new pathogen of basal stem rot of Schisandra chinensis in Jilin Province, China

Frontiers in Microbiology
IntroductionSchisandra chinensis (Turcz.) Baill. is a widely cultivated medicinal plant with significant economic value and serves as a major component of specialty agriculture in Jilin Province, China.
Taiping Tian, Mengqi Wang, Jingmeng Zhu, Yining Sun, Mingjie Ma, Guoliang Liu, Jinshuo Wang, Bing Zhao, Yiping Yan, Yue Wang, Yue Wang, Yanli Wang, Yanli Wang, Changyu Li, Changyu Li, Dongyin Wang, Fang Yang, Wenpeng Lu, Wenpeng Lu, Peilei Xu, Peilei Xu   +20 more
doaj   +1 more source