Results 61 to 70 of about 75,809 (306)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Propagation of Medicinal Plants for Sustainable Livelihoods, Economic Development, and Biodiversity Conservation in South Africa

, 2023
South Africa is blessed with vast plant resources and unique vegetation types. Indigenous South African medicinal plants have been well-harnessed to generate income in rural communities.
Olaoluwa O. Olarewaju, Johannes Van Staden, Olufunke O. Fajinmi   +2 more
core   +1 more source

Effect of Leaf Segments and Potting Media on Plant Performance of Sansevieria trifasciata Hort. ex Prain Grown under Ex vitro Conditions

Turkish Journal of Agriculture: Food Science and Technology, 2019
The present study was conducted to investigate the vegetative propagation of Sansevieria trifasciata under ex vitro conditions. The experiment was conducted at the net house to select the best leaf segment among apical, middle and bottom portions of ...
Alaguthurai - Hematharshini, Thayamini Harold Seran   +1 more
doaj   +1 more source

The Effect of Different Applications on In vitro Bulb Development of an Endemic Hyacinth Plant (Hyacinthus orientalis L. subsp. chionophyllus Wendelbo) Grown in Turkey

Turkish Journal of Agriculture: Food Science and Technology, 2020
In this study the effects of different sucrose concentrations, and the combinations of jasmonic acid (JA) with auxins (IAA or NAA) or with cytokinin (2iP) on the bulb induction and rooting of in vitro plantlets of Hyacinthus orientalis subsp ...
Selay Doğan, Gülat Çağlar, Esra Bulunuz Palaz   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Screening of Apple Cultivars for Scab Resistance in Kazakhstan

Horticulturae
Scab, caused by Venturia inaequalis, is the most destructive fungal disease of apple worldwide. Apple scab incidence was studied in apple orchards in the south and southeast of Kazakhstan, including the Almaty, Zhambyl, and Turkestan regions, during 2022
Aigul Madenova, Zhankeldy Aitymbet, Munira Bolat, Dinara Kaldybayeva, Kanat Galymbek, Angsagan Kuan, Balnur Kabylbekova, Azhargul Irkitbay, Tynyshbek Yeszhanov, Serik Bakirov, Zagipa Sapakhova   +10 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Plant Propagation

, 1989
viii,286 hal,;ill,;21 ...
Sadhu,M.K
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Flowering and vegetative propagation of pyrethrum (Chrysanthemum cinerariaefolium Vis.) in vivo and in vitro

, 1976
The influence of climatic conditions was investigated on flowering behaviour of pyrethrum ( Chrysanthemum cinerariaefolium Vis.). At low temperatures high numbers of plants initiated high numbers of flower heads.
Roest, S.
core