Results 101 to 110 of about 6,264,471 (313)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth

Nature Communications, 2016
Perturbations in ribosome biogenesis affect development and increase cancer susceptibility. Here, the authors show that hCINAP is required for 18S rRNA processing, is highly expressed in cancers, and promotes cancer cell growth by upregulating the ...
Dongmei Bai, Jinfang Zhang, Tingting Li, Runlai Hang, Yong Liu, Yonglu Tian, Dadu Huang, Linglong Qu, Xiaofeng Cao, Jiafu Ji, Xiaofeng Zheng   +10 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Toward a Molecular Understanding of Plant Hormone Actions [PDF]

, 2016
Plants rely on a diverse set of small-molecule hormones to regulate every aspect of their biological processes including development, growth, and adaptation. Since the discovery of the first plant hormone, auxin, hormones have always been at the frontier
Matsuoka, M., Lee, Y., Li, Jiayang, Matsuoka, Makoto, Li, J.Y., Schroeder, J., Lee, Youngsook, Leung, Jeffrey, Zhao, Y.D., Harter, Klaus, Qu, L.J., Li, C.Y., Li, Chuanyou, Offringa, Remko, Qu, Lijia, Martinoia, Enrico, Zhao, Yunde, Chong, K., Offringa, R., Leung, J., Schroeder, Julian, Harter, K., Chong, Kang, Martinoia, E.   +23 more
core   +1 more source

Human activities reshape the spatial overlap between North Chinese leopard and its wild ungulate prey

Frontiers in Zoology
Background Rapidly expanding human activities have profoundly changed the habitat use of both large carnivores and their prey, but whether and how human activities affect the interactions between them has received relatively less attention. In this study,
Yidan Wang, Mingzhang Liu, Fan Xia, Sheng Li   +3 more
doaj   +1 more source

Viral-inducible Argonaute18 confers broad-spectrum virus resistance in rice by sequestering a host microRNA

eLife, 2015
Viral pathogens are a major threat to rice production worldwide. Although RNA interference (RNAi) is known to mediate antiviral immunity in plant and animal models, the mechanism of antiviral RNAi in rice and other economically important crops is poorly ...
Jianguo Wu, Zhirui Yang, Yu Wang, Lijia Zheng, Ruiqiang Ye, Yinghua Ji, Shanshan Zhao, Shaoyi Ji, Ruofei Liu, Le Xu, Hong Zheng, Yijun Zhou, Xin Zhang, Xiaofeng Cao, Lianhui Xie, Zujian Wu, Yijun Qi, Yi Li   +17 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Proteomic Analysis of Chloroplast-to-Chromoplast Transition in Tomato Reveals Metabolic Shifts Coupled with Disrupted Thylakoid Biogenesis Machinery and Elevated Energy-Production Components [PDF]

, 2012
A comparative proteomic approach was performed to identify differentially expressed proteins in plastids at three stages of tomato(Solanum lycopersicum) fruit ripening (mature-green, breaker, red). Stringent curation and processing of the data from three
Bouyssie, David, Bian, Wanping, Barsan, Cristina, Rossignol, Michel, Bouzayen, Mondher, Picheraux, Carole, Latché, Alain, Egea Sanchez, Isabel, Pech, Jean-Claude, Pichereaux, Carole, Maza, Elie, Egea, Isabel, Zouine, Mohamed, Zouine, Mohammed, Purgatto, Eduardo   +14 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source