Results 141 to 150 of about 1,346,458 (344)

Application of multivariate analysis to electrical penetration graphs using manual and automate waveform recognization from the planthopper Peregrinus maidis feeding on susceptible and resistant maize [PDF]

, 2004
The stylet penetration activities of Peregrinus maidis (Ashmead) (Homoptera: Delphacidae), vector of Maize mosaic virus (MMV) and Maize stripe virus (MStV) were studied by electrical penetration graphs (DC-EPG) on resistant and susceptible maize inbred ...
Buduca, Cécile, Chiroleu, Frédéric, Dintinger, Jacques, Grondin, Martial, Lecoq, Julien, Turpin, Patrick   +5 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Impact of graphene oxide disturbance on the structure and function of arbuscular mycorrhizal networks

Ecotoxicology and Environmental Safety
With the widespread application of graphene oxide (GO), its potential toxicity has received increasing attention. The extraradical mycelium of arbuscular mycorrhizal fungi (AMF) can extend from the roots of one plant to those of another, forming complex ...
Lian Duo, Hang Su, Jiayi Li, Qi Wang, Shulan Zhao   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Virulence and genetic characterization of Puccinia striiformis f.sp. tritici populations on different wheat cultivars

Phytopathology Research
Wheat stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a major global threat to wheat production, severely affecting yield stability.
Jierong Wang, Yongjin Jin, Li Geng, Hongyan Wang, Jing Zhao, Lili Huang, Zhensheng Kang, Gangming Zhan   +7 more
doaj   +1 more source

Arabidopsis Plants Sense Non-self Peptides to Promote Resistance Against Plectosphaerella cucumerina

, 2020
Julia Pastor-Fernández, Jordi Gamir, Victoria Pastor, Paloma Sánchez‐Bel, Neus Sanmartín, Miguel Cerezo, Vı́ctor Flors   +6 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Additional file 2 of Lyso-phosphatidylethanolamine primes the plant immune system and promotes basal resistance against hemibiotrophic pathogens

, 2021
Ronny Völz, Ju Young Park, William Harris, Sungkee Hwang, Yong‐Hwan Lee   +4 more
openalex   +1 more source

Disease resistant plants

, 2007
The present invention relates to methods for producing plants having enhanced disease resistance. NRCl proteins and nucleic acid sequences encoding these are provided, as well as transgenic plants producing NRCl proteins.
Gabriëls, S.H.E.J., Vossen, J.H., Joosten, M.H.A.J., de Wit, P.J.G.M.   +3 more
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source