Results 161 to 170 of about 1,346,458 (344)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

New witches broom QTL in the Sca 6 x ICS 1 F2 population [PDF]

, 2011
Witches´ broom disease (WBD) of cacao, caused by the basidiomicete Moniliophthora perniciosa, is one of the most important diseases of cacao, the chocolate tree (Theobroma cacao L.).
Aguiar, R.S., Clément, Didier, Gramacho, Karina Peres, Juca, F.F., Lopes, Uilson Vanderlei, Mello, J.M.R., Nascimento, A.P.S., Pires, J.L., Santos, Rogério M.F.   +8 more
core  

Challenges to the exploitation of host plant resistance for Striga management in cereals and legumes by farmers in sub-Saharan Africa: a review

, 2018
Ronald Mandumbu, Charles Shelton Mutengwa, Stanford Mabasa, Eddie Mwenje   +3 more
openalex   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Zinc metalloprotease FgM35, which targets the wheat zinc-binding protein TaZnBP, contributes to the virulence of Fusarium graminearum

Stress Biology
Metalloproteinases are ubiquitous in organisms. Most metalloproteinases secreted by pathogenic microorganisms are also called virulence factors, because they degrade proteins in the external tissues of the host, thereby reducing the host’s immunity and ...
Xin-tong Wang, Kou-han Liu, Ying Li, Yan-yan Ren, Qiang Li, Bao-tong Wang   +5 more
doaj   +1 more source

Characterization of peroxidase and catalase genes in defense mechanisms of Physcomitrella patens [PDF]

, 2019
Systemic acquired resistance (SAR) and the hypersensitive response (HR) are two important induced defense mechanisms in plants. SAR is the development of an enhanced resistance to a pathogen due to a prior encounter.
Ciulla, Lauren
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Proceedings of the COST SUSVAR/ECO-PB Workshop on organic plant breeding strategies and the use of molecular markers [PDF]

, 2005
In many countries,national projects are in progress to investigate the sustainable low-input approach.In the present COST network,these projects are coordinated by means of exchange of materials,establishing common methods for assessment and statistical ...

core  

Overexpression of the Tomato Asc-1 Gene Mediates High Insensitivity to AAL Toxins and Fumonisin B₁ in Tomato Hairy Roots and Confers Resistance to Alternaria alternata f. sp. lycopersici in Nicotiana umbratica Plants

, 2002
B.F. Brandwagt, Tarcies J. A. Kneppers, H. John J. Nijkamp, Jacques Hille   +3 more
openalex   +2 more sources

ROLE OF TOTAL PHENOL IN THE RESISTANCE MECHANISM OF PLANTS AGAINST AIR POLLUTION

, 2022
Deepika Chandawat, P.U Verma, Hitesh Solanki, Hitesh Solanki   +3 more
openalex   +2 more sources