We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Overexpression of the <i>Salix matsudana</i> aquaporin gene <i>SmPIP1;3</i> enhances plant resistance to abiotic stresses. [PDF]
Xu X, Yin P, Wang L, Lu X, Xu J.
europepmc +1 more source
Overexpression of Arabidopsis ACBP3 Enhances NPR1-Dependent Plant Resistance to Pseudomonas syringe pv tomato DC3000 [PDF]
Shi Xiao, Mee‐Len Chye
openalex +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Water immunity overrides stomatal immunity in plant resistance to Pseudomonas syringae. [PDF]
Kemppinen J +4 more
europepmc +1 more source
Plant resistance against whitefly and its engineering. [PDF]
Li D +6 more
europepmc +1 more source
What happens when ants fail at plant defence?
Megan E. Frederickson +5 more
openalex +1 more source
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Utilizing genetic variation in perennial sorghum to improve host plant resistance to aphids. [PDF]
Kaler E +4 more
europepmc +1 more source

