Results 101 to 110 of about 195,044 (308)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The Dynamics of Cell-to-Cell Water Transport and the Involvement of Aquaporins in Response to Apoplast Blockage in the Roots of Intact Maize Plants

Cells
Investigating the contribution and interaction of water transport pathways in plant roots is important for understanding the functioning of the root hydraulic system. In this study, the real-time dynamics of lateral water transport along the cell-to-cell
Maksim Suslov
doaj   +1 more source

Effect of mineral nutrition on metabolic change induced in crop plant roots (V) [PDF]

, 1967
Saburo Okamoto
openalex   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Bacterial and Fungal Diversity from the Rhizosphere of Plants Wildly Growing in Agricultural Soil Under Unfavourable Environmental Conditions

Biology and Life Sciences Forum
Rhizospheres harbor many beneficial microorganisms interacting with the plant ecosystem. However, in agriculture, there is a tendency to remove any plant that is different from that being cultivated.
Marta Adalia-Mínguez, Esther Morate-Gutiérrez, Lilyana Tihomirova-Hristova, Sandra Bielsa-Lozoya, Alicia Rodríguez-Cárdenas, Miguel Martínez-Illana, Belén Álvarez   +6 more
doaj   +1 more source

Spontaneous symbiotic reprogramming of plant roots triggered by receptor-like kinases

, 2014
Martina Katharina Ried, Meritxell Antolín‐Llovera, Martin Parniske   +2 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Root Pruning Enhances Leaf Oxidative Stress and Anthocyanin Accumulation in Hydroponically Grown Red Leaf Lettuce

Oxygen
Root pruning has been proposed as a practical method to regulate growth and metabolite accumulation in horticultural crops, yet its physiological and metabolic consequences in hydroponically grown lettuce remain poorly understood.
Masaru Sakamoto, Takahiro Suzuki
doaj   +1 more source

Overexpression of the Tomato Asc-1 Gene Mediates High Insensitivity to AAL Toxins and Fumonisin B₁ in Tomato Hairy Roots and Confers Resistance to Alternaria alternata f. sp. lycopersici in Nicotiana umbratica Plants

, 2002
B.F. Brandwagt, Tarcies J. A. Kneppers, H. John J. Nijkamp, Jacques Hille   +3 more
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source