Results 101 to 110 of about 4,262,374 (335)
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Study on the mechanism of plant root influence on soil properties in expansive soil areas
Open GeosciencesExpansive soil is a type of unsaturated soil that develops fissures within its body due to dry and wet cycles. These fissures are the primary factor contributing to slope instability in expansive soil regions.
Tingting Cao +5 more
doaj +1 more source
Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice
FEBS Letters, EarlyView.In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász +6 more
wiley +1 more source
Growing aridity poses threats to global land surface
Communications Earth & EnvironmentGlobal warming has impacted water cycle, but not exist a global study of the changes at global scale of the impacts on water available for plants. Here, cloud-optimized monthly aggregated climate reanalysis from the European Centre for Medium-Range ...
Jordi Sardans +5 more
doaj +1 more source
SUGAR MOVEMENT TO ROOTS, MINERAL UPTAKE, AND THE GROWTH CYCLE OF THE COTTON PLANT [PDF]
, 1944 Frank M. Eaton, Howard E. Joham
openalex +1 more source
Sampling roots to capture plant and soil functions
, 2017 Summary Roots vary in anatomy, morphology and physiology, both spatially (different parts of the same root system) and temporally (plastic changes, root ageing), suggesting that root trait measurements are strongly affected by root sampling categories.
G. T. Freschet, C. Roumet
semanticscholar +1 more source
Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases
FEBS Letters, EarlyView.
Igor Zivkovic +2 more
wiley +1 more source