Results 221 to 230 of about 2,784,419 (339)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

The INDEPTH (Impact of Nuclear Domains on Gene Expression and Plant Traits) Academy: a community resource for plant science. [PDF]

J Exp Bot, 2022
Tatout C, Mougeot G, Parry G, Baroux C, Pradillo M, Evans D.   +5 more
europepmc   +1 more source

La physique des arbres : où il est traité de l'anatomie des plantes et de l'économie végétale: pour servir d'introduction au traité complet des bois & des forests: avec une dissertation sur l'utilité des méthodes de botanique ; & une explication des termes propres à cette science, & qui sont en usage pour l'exploitation des bois & des forêts

Duhamel du Monceau
openalex   +2 more sources

National Science Foundation-Sponsored Workshop Report: “The 2010 Project”Functional Genomics and the Virtual Plant. A Blueprint for Understanding How Plants Are Built and How to Improve Them [PDF]

, 2000
Joanne Chory, Joseph R. Ecker, Steve Briggs, Michel Caboche, Gloria M. Coruzzi, Doug Cook, Jeffrey L. Dangl, Sarah R. Grant, Mary Lou Guerinot, Steven Henikoff, Rob Martienssen, Kiyotaka Okada, Natasha V. Raikhel, Chris Somerville, Detlef Weigel   +14 more
openalex   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Policy influence 2023: Societal impact at Plants, People, Planet

Plants, People, Planet
Simon Hiscock, Sarah Lennon, Bennett Young   +2 more
doaj   +1 more source

The NMR Microscope: a Unique and Promising Tool for Plant Science [PDF]

, 2000
N. Ishida
openalex   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Broadening the impact of plant science through innovative, integrative, and inclusive outreach. [PDF]

Plant Direct, 2021
Friesner J, Colón-Carmona A, Schnoes AM, Stepanova A, Mason GA, Macintosh GC, Ullah H, Baxter I, Callis J, Sierra-Cajas K, Elliott K, Haswell ES, Zavala ME, Wildermuth M, Williams M, Ayalew M, Henkhaus N, Prunet N, Lemaux PG, Yadegari R, Amasino R, Hangarter R, Innes R, Brady S, Long T, Woodford-Thomas T, May V, Sun Y, Dinneny JR.   +28 more
europepmc   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source