Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Production of Ornithogalum spp. floral stems as a function of bulb mass
Pesquisa Agropecuária TropicalAmong ornamental species, Ornithogalum spp. has a high commercial potential, and bulb size is a determining factor for production success. This study aimed to evaluate the influence of bulb mass on the production and quality of floral stems.
Elaidy Laura Oliveira Cardoso +7 more
doaj +1 more source
Responses of Biennial Sweetclovers of Diverse Latitudinal Adaptation to Various Management Procedures in Alaska [PDF]
, 1994 This report summarizes eight experiments with sweetclover (Melilotus species). Objectives were (a) determine responses of numerous cultivars and strains, representing a wide range of latitudinal adaptation, to various management procedures, (b ...
Klebesadel, Leslie J.
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Introducing the genus Phedimus [PDF]
, 2017 The Eurasian genus Phedimus is a member of the Crassulaceae, first described 200 years ago in 1817, so its bicentennial is worthy of celebration.
Walker, Colin C.
core
The role of refugia plants to the eggs yellow rice stem borer (Scirpophaga incertulas Walker) parasitoids parasitation rate [PDF]
, 2018 Masnita Br Sitepu +2 more
openalex +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
ENVIRONMENTAL VARIABLES ASSOCIATED WITH INVASIVE GLOSSY BUCKTHORN (FRANGULA ALNUS MILL.) AND INDIRECT CONTROL STRATEGIES FOR FOREST MANAGERS [PDF]
, 2016 Glossy buckthorn (Frangula alnus Mill.) is one of the most prominent non-native invasive plant species affecting New England forests. It quickly invades a forest and can create a dense understory effectively altering the species composition and dynamics
KOZIKOWSKI, JOSHUA GLIDDEN
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Frontiers in Plant ScienceCarbon (C), nitrogen (N), and phosphorus (P) stoichiometry serve as valuable indices for plant nutrient utilization and biogeochemical cycling within ecosystems.
Lei Wang +10 more
doaj +1 more source